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Dyspepsia: Celiac Disease is Twice as Common in People with Dyspepsia
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
Bardella MT, Minoli G, Ravizza D, et al Arch Intern Med. 2000 May 22;160(10):1489-91
(Celiac.com 07/09/2000) Approximately 30% to 40% of patients with celiac disease (which affects at least 1 in 200 individuals) also have symptoms of dyspepsia. There is, however, a lack of data regarding the prevalence of celiac disease in patients with dyspepsia.
Methods: All outpatients who underwent an endoscopy of the upper gastrointestinal tract for dyspepsia were enrolled at our center between January and June 1998. All patients under 12 years old were excluded, as were all patients who had been diagnosed with other gastrointestinal diseases, were suspected to have celiac disease, or had malabsorption, and/or iron-deficiency anemia.
Results: 517 (17%) out of 3,019 patients (age range, 20-46 years) were eligible for the study. Endoscopic findings suggested celiac disease in 5 cases, and was histologically diagnosed in 6 of the patients (5 women and 1 man; mean age, 31.3 years). Of the six, 3 had a normal endoscopic pattern, and 3 had a pattern that was consistent with celiac disease. Follow up antiendomysium antibody positivity supported the diagnosis in the patients with histologically diagnosed celiac disease. The relative risk for celiac disease was 2.32 (95% confidence interval, 1.06-5.07) in comparison with the general population, and it was higher among females (3.22; 95% confidence interval, 1.37-7.56).
Conclusions: The prevalence of celiac disease in patents with dyspepsia is twice that of the general population. As a result, serological screening for celiac disease should be considered in the early workup of these patients to allow diagnosis and treatment of what is a treatable disease.
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No Increased Risk of Celiac Disease for People with Eosinophilic Esophagitis and Gastroesophageal Reflux Disease
Celiac disease has been linked to gastroesophageal reflux disease (GORD) and eosinophilic esophagitis (EoE), but there is very little data from population-based studies on the rates of shared disease among these groups.... [READ MORE]
A Gluten Free Diet May Alleviate Gastroesophageal Reflux Symptoms in People with Celiac Disease
To date, symptoms of gastroesophageal reflux disease (GERD) - heartburn and acid regurgitation - have been among the only GI symptoms absent from the list of common manifestations of celiac disease.... [READ MORE]