No popular authors found.

Categories

No categories found.


Join Celiac.com's forum / message board and get your questions answered! Our forum has nearly 1 MILLION POSTS, and over 62,000 MEMBERS just waiting to help you with any questions about celiac disease and the gluten-free diet. We'll see you there!






Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus RSS Podcast Email  Get Email Alerts

SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Celiac Disease in the Year 2000: Exploring the Iceberg

Abstract for the Italian study:
Catassi C; Ratsch IM; Fabiani E; Rossini M; Bordicchia F; Candela F; Coppa GV; Giorgi PL
Coeliac Disease in the Year 2000: Exploring the Iceberg [see comments]
Department of Pediatrics, University of Ancona, Italy.
Source: Lancet 1994 Jan 22; Vol. 343(8891):200-3
Comment in: Lancet 1994 Jan 22; Vol. 343(8891):188
Comment in: Lancet 1994 Mar 12; Vol. 343(8898):675
Comment in: Lancet 1994 Apr 16; Vol. 343(8903):984

Unique Identifier: 94118649 It is now generally believed that sub-clinical Coeliac disease is common in the general population. We have undertaken screening for this disorder in a school district in central Italy. Screening was divided into three levels: first, IgG and IgA antigliadin antibody (AGA) assay on capillary blood obtained by finger prick; second, AGA plus IgA anti-endomysium antibody (AEA) test and measurement of serum immunoglobulins in venous blood; and third, intestinal biopsy. 3351 students (66% of the eligible population) aged 11-15 years attended first-level screening. 71 (2%) were recalled because of AGA positivity; 18 of these satisfied second-level criteria and underwent intestinal biopsy.

Coeliac disease was diagnosed in 11 subjects, most of whom had no serious symptoms. Selective IgA deficiency was found in 4 subjects, 1 of whom also had coeliac disease. The prevalence of sub-clinical coeliac disease in the study group was 3.28 per 1000*. Coeliac disease screening is feasible and involves only slight discomfort to the general population. Such screening can detect large numbers of cases of Coeliac disease, which can be treated with a gluten-free diet. Many sub-clinical cases of Coeliac disease would not be detected by screening only a selected group of at-risk patients.

The following chart summarizes the study:

No. of Students in Study No. Positive for IgG and IgA Antigliadin Antibodies No. Positive for AGA plus IgA Anti-Endomysium Antibodies No. w/ Positive Intestinal Biopsy
3,351 ( = 100%) 71 ( = 2.1%) 18 ( = 0.537%) 11 ( =.328%)

*Please note that the finding in this study of 3.28 per 1000 includes only those who satisfied all criteria of diagnosis, including a biopsy. Many of the original 71 kids (2%) who tested positive for IgG and IgA antigliadin antibodies may later develop typical or atypical symptoms, and have positive intestinal biopsies.

Celiac.com welcomes your comments below (registration is NOT required).



Related Articles




Spread The Word





Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *: