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The Role of Zonulin and Intestinal Permeability in Celiac Disease
- By Scott Adams
- Published 11/8/2005
- Celiac Disease Diagnosis, Testing & Treatment (Gluten-Free Diet)
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Scott Adams
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed and living happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease, and since then it has become an invaluable resource to people worldwide who seek information about celiac disease and the gluten-free diet.
In 1998 I created The Gluten-Free Mall, Your Special Diet Superstore! which was also another Internet first—it was the first gluten-free food site to offer a shopping cart-style interface, and the ability for people to order gluten-free products manufactured by many different companies at a single Web site.
The Role of Zonulin and Intestinal Permeability in Celiac Disease
Published in the November issue of the Scandinavian Journal of Gastroenterology, these results describe the role that leaky gut plays in celiac disease and the role that zonulin plays in establishing the leak. These results are another milestone towards understanding the role of zonulin in celiac disease, says Alessio Fasano, M.D., lead author of the paper, professor of pediatrics, medicine and physiology at the University of Maryland School of Medicine and director of its Center for Celiac Research.
These results reinforce our conviction that AT-1001 has great therapeutic potential and we look forward to confirming these observations in celiac patients soon, stated Alba CEO Dr. Blake M. Paterson.
About Zonulin
Zonulin is a signaling protein that transiently and reversibly opens the
tight junctions (tj) between the cells of epithelial and endothelial
tissues such as the intestinal mucosa, blood brain barrier and pulmonary
epithelia. Zonulin appears to be involved in many diseases in which leakage
occurs via paracellular transport across epithelial and endothelial tight
junctions (tj),
and thus may play an important potential role in the treatment of autoimmune
diseases.
About Celiac Disease
Celiac disease is a T-cell mediated auto-immune disease that occurs in
genetically susceptible individuals and is characterized by small intestinal
inflammation, injury and intolerance to gluten. According to the National
Institutes of Health, celiac disease affects approximately 3 million Americans,
although the diagnosis is rarely made. The only treatment for celiac disease is complete
elimination of gluten from the diet, which results in remission for some
patients.
About Alba
Alba Therapeutics Corporation is a privately held biopharmaceutical company
based in Baltimore, Maryland. Alba is dedicated to commercializing disease-modifying
therapeutics and drug delivery adjuvants based on the zonulin pathway.
Albas lead molecule, AT-1001, is targeted towards the treatment of celiac
disease and other auto-immune illnesses.
Contact: Dr. Blake Paterson
Alba Therapeutics Corporation
(410) 522-8708
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