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Papain And Bromelain?

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Posted 14 July 2006 - 08:00 PM

My coach, who reads a zillion articles about everything and knows about everything, mentioned this, but he doesn't know if it would work. Of course, he wouldn't tell me to just eat gluten, but if I were about to go out to eat or encounter a meal that I suspected might have CC or something, it might help.

Quoted from him:
Did you see this one too?


I just got an idea skimming these papers: It would seem that the
Peptides (not the constituent amino acids) are the problem irritating
The bowel and causing symptoms.

If that's so, then if you ingested enzymes to help break down those
Peptide BEFORE they reached the small intestine, you might be able
To reduce or eliminate symptoms. That's the theory anyway.

If you look in Vitamin World or online at www.puritanspride.com


They have both bromelain and papain enzyme tablets which help to break down
Protein. If the offending peptides are broken up into constituent aminos by
The time they hit your gut, they might not cause problems (??)

I have a recipe for a marinade that is based on papaya and pineapple and I
Have to tell you this stuff can "digest" chicken breasts in under a 1/2
(its really yummy tho :-) ) So in the same way that taking enzymes to break
Lactose can help the lactose intolerant, I'm wondering if these proteolytic
Enzymes might not help the gluten intolerant.
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Posted 14 July 2006 - 08:20 PM

Interesting recipe idea. I take v-gest which helps some, but it doesn't "cure" the problem. I take it because so many foods cause problems with me, but the enzymes can't "cure" celiac disease-it is an autoimmune reaction to the gluten containing foods that cause the problems. I think anything that helps to normalize the intestines is a good idea and someone like myself who has had long term D probably has a deficiency of many enzymes. I am sure the constipation sufferers also would get benefits from enzymes. Thanks for the interesting topic.
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Posted 15 July 2006 - 08:00 AM

In the media I have seen several times lately the assertion that Celiac disease is caused by the inability to break down gluten, i.e., the lack of an ezyme or something. I'm not sure that is the nature of the disease. My understanding is that it is actually an abnormal immune response to gluten rather than in inability to break it down.
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Posted 15 July 2006 - 08:28 AM

In the media I have seen several times lately the assertion that Celiac disease is caused by the inability to break down gluten, i.e., the lack of an ezyme or something. I'm not sure that is the nature of the disease. My understanding is that it is actually an abnormal immune response to gluten rather than in inability to break it down.

I've noticed that, too. Either that or they say 'unable to digest gluten'. Neither are correct--the body treats gluten as an invader and triggers a reaction. The immune system in turn attacks the lining of the small intestine. You are right :D

I almost forgot why I posted here in the first place :blink: --my local health food store carries it's own brand of Papain and Bromelain. I find it very soothing. I use it instead of things like Tums.
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Posted 15 July 2006 - 09:34 AM

I didn't think it would work for that reason.

I feel like there's a lot more to celiac disease than we know, though. I don't think it's just that we can't handle gluten, but there's something wrong with us, and gluten-intolerance is a by-product.
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Posted 15 July 2006 - 09:06 PM

I didn't think it would work for that reason.

I feel like there's a lot more to celiac disease than we know, though. I don't think it's just that we can't handle gluten, but there's something wrong with us, and gluten-intolerance is a by-product.

I think you may be right about that. Really, Celiac disease seems to be part of a syndrome pattern when you consider all the various spinoffs it has and not all of them can be explained by malabsorption. For a lot of people, there are problems that persist even after they go gluten free.

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Posted 16 July 2006 - 01:53 AM

papain and bromelain are digestive enzymes. If you pick up any bottle at the health food store you will see them listed as ingredients. I love digestive enzymes. Sometimes when I eat safe food (more when I was recently gluten-free) my stomach would hurt. Taking one of these before meals really cut down on my stomach aches because they do help you digest your food.

And, the new research out of Stanford is working with some type of enzyme that will digest small amounts of gluten, like from cc, so you don't get sick. That is years away and probably not anything like the enzymes we can buy now. I don't think this research would be in the news if we could just pop any of these gluten-ease or other things in the health food stores that claim they can help you digest gluten. Even those things say they are not for celiacs.

Regular digestive enzymes will help you digest your food better but won't allow you to eat gluten. I have taken them a lot and I have never noticed a reduction in my symptoms from being glutened when I am taking them. I am also very sensitive and I don't think it has helped me be able to tolerate small amounts of gluten.
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Posted 11 August 2006 - 11:42 AM

Somehow I missed this topic but I ran across some very interesting research with regards to Bromelain. That leads me to believe that in the right quantity it won't cure, but I'm guessing it can help.

Here's what I posted elsewhere with regards to this.

Anyone tried Bromelain as an anti-inflammitory for MC (Microscopic Colitis)? My naturapath suggested taking this on an empty stomach. Doing some research it sounds promising. It's a digestive enzyme made from pineapple stem. What is of further interest is that it was also shown to help with E. Coli... there we go again with bacteria and links to inflamation.

Ann Intern Med. 2000 Apr 18;132(8):680.
Use of Bromelain for Mild Ulcerative Colitis
To the Editor: Ulcerative colitis is a chronic condition characterized
by inflammation of the mucosal layer of the colon. Despite
multiple treatments, some patients continue to be symptomatic
and seek alternative therapy. We describe two patients
who achieved clinical and endoscopic remission after initiation of
bromelain supplementation.
A 67-year-old woman with a history of ulcerative proctitis
continued to have three to four bloody bowel movements per day
despite adequate doses of sulfasalazine, mesalamine, and topical
steroids. She discovered bromelain at a nutrition/herbal store
after researching “digestive aids” and anti-inflammatory drugs.
Within a week of taking two tablets of bromelain at each meal,
she was having one formed bowel movement per day without
blood or urgency. Endoscopy performed at that time revealed
healed mucosa.
The second patient is a 60-year-old woman with a history of
left-sided disease; her symptoms continued despite azathioprine,
2 mg/kg of body weight, and topical mesalamine. She had heard
about bromelain from a friend who used it for “colonic health.”
After she took several doses, her diarrhea improved. Endoscopy
revealed quiescent disease affecting the splenic flexure.
Bromelain is a proteolytic enzyme isolated from the pineapple
stem. Anecdotal use of bromelain alone includes the successful
treatment of inflamed joints, dental pain, and postsurgical pain
and inflammation, presumably through an anti-inflammatory
mechanism, inhibition of platelet aggregation, or fibrinolytic activity.
Published reports on bromelain use refer to experimental
animal models of inflammation (1) and one double-blinded study
in humans revealing efficacy in healing noninfectious cystitis (2).
Bromelain in the treatment of infectious colitis with enterotoxigenic
Escherichia coli has recently been described (3). This
therapy had a proteolytic effect on the specific receptors of K881
enterotoxigenic E. coli in the small intestines of piglets, thereby
preventing bacterial attachment and subsequent infection. In ulcerative
colitis, bromelain may act by way of fibrinolysis, a mechanism
not unlike that reported in previous trials with heparin (4, 5).
Sunanda Kane, MD, MSPH
Michael J. Goldberg, MD
University of Chicago Hospitals
Chicago, IL 60637
1. Smyth RD, Moss JN, Brennan R, Harris JC, Martin GJ. Biochemical
studies on the resolution of experimental inflammations in animals
treated with bromelain. Exp Med Surg. 1967;25:229-35.
2. Lotti T, Mirone V, Imbimbo C, Corrado F, Corrado G, Garofalo F, et
al. Controlled clinical studies of nimesulide in the treatment of urogenital
inflammation. Drugs. 1993;46(Suppl 1):144-6.
3. Chandler DS, Mynott TL. Bromelain protects piglets from diarrhea
caused by oral challenge with K88 positive enterotoxigenic Escherichia
coli. Gut. 1998;43:196-202.
4. Folwaczny C, Wiebecke B, Loeschke K. Unfractionated heparin in the
therapy of patients with highly active inflammatory bowel disease. Am J
Gastroenterol. 1999;94:1551-5.
5. Evans RC, Wong VS, Morris AI, Rhodes JM. Treatment of corticosteroid
dependent ulcerative colitis with heparin—a report of 16 cases.
Aliment Pharmacol Ther. 1997;11:1037-40.

Clin Immunol. 2005 Aug;116(2):135-42. Links
Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.
Hale LP, Greer PK, Trinh CT, Gottfried MR.
Department of Pathology, DUMC 3712, Duke University Medical Center, Durham, NC 27710, USA. laura.hale@duke.edu

Bromelain is a mixture of proteinases derived from pineapple stem that is marketed in health food stores as a "digestive aid". Orally administered bromelain was anecdotally reported to induce clinical and endoscopic remission of ulcerative colitis in two patients whose disease was refractory to multi-agent conventional medical therapy. However, the potential efficacy of bromelain in colitis has not yet been tested rigorously in either animals or humans. In this study, the clinical and histologic severity of inflammatory bowel disease (IBD) was determined in IL-10-/- mice treated orally with bromelain in vivo. Daily treatment with oral bromelain beginning at age 5 weeks decreased the incidence and severity of spontaneous colitis in C57BL/6 IL-10-/- mice. Bromelain also significantly decreased the clinical and histologic severity of colonic inflammation when administered to piroxicam-exposed IL-10-/- mice with established colitis. Proteolytically active bromelain was required for anti-inflammatory effects in vivo. Adverse effects of dermatitis, hair loss, and weight loss due to mucositis were rare, dose related, and were not seen in wild-type mice treated orally with up to 1000 mg bromelain/kg/day for 18 weeks. Although the exact mechanisms by which exogenous proteinases affect bowel inflammation have not yet been determined, the results justify additional studies of this complementary biologically based approach to treatment of IBD.

Here's more:

This just hit me, given that IBD seem to be hitting developed nations more than others. And given that developed nations has so many refined foods, removing everything that is "unappetizing" from our natural food sources (stems, seeds, husks, roots, leaves all the stuff from which these digestive enzymes seem to be created from) that we have removed a source of health/healing for our GI and we get ill. We get sicker as we get cleaner. Hmmmm... :)

Hell, it looks like enzymes in general can help, not just this particular one.

Med Hypotheses. 2006 Jul 24;

Where do the immunostimulatory effects of oral proteolytic enzymes ('systemic enzyme therapy') come from? Microbial proteolysis as a possible starting point.

Biziulevicius GA.

Laboratory of Immunopharmacology, Institute of Immunology, Vilnius University, 29 Moletu plentas, LT-08409 Vilnius, Lithuania.

Enteric-coated proteolytic enzyme preparations like Wobenzym(®) and Phlogenzym(®) are widely used for the so-called 'systemic enzyme therapy' both in humans and animals. Numerous publications reveal that oral proteolytic enzymes are able to stimulate directly the activity of immune competent cells as well as to increase efficiency of some of their products. But origins of the immunostimulatory effects of oral proteolytic enzymes are still unclear. The hypothesis described here suggests that it may be proteolysis of intestinal microorganisms that makes the immune competent cells to work in the immunostimulatory manner. The hypothesis was largely formed by several scientific observations: First, microbial lysis products (lipopolysaccharides, muropeptides and other peptidoglycan fragments, beta-glucans, etc.) are well known for their immunostimulatory action. Second, a normal human being hosts a mass of intestinal microorganisms equivalent to about 1kg. The biomass (mainly due to naturally occurring autolysis) continuously supplies the host's organism with immunostimulatory microbial cell components. Third, the immunostimulatory effects resulting from the oral application of exogenously acting antimicrobial (lytic) enzyme preparations, such as lysozyme and lysosubtilin, are likely to be a result of the action of microbial lysis products. Fourth, cell walls of most microorganisms contain a considerable amount of proteins/peptides, a possible target for exogenous proteolytic enzymes. In fact, several authors have already shown that a number of proteases possess an ability to lyse the microbial cells in vitro. Fifth, the pretreatment of microbial cells (at least of some species) in vitro with proteolytic enzymes makes them more sensitive to the lytic action of lysozyme and, otherwise, pretreatment with lysozyme makes them more susceptible to proteolytic degradation. Sixth, exogenous proteases, when in the intestines, may participate in final steps of food-protein digestion. The resulting food-borne peptides have recently been shown to be potential activators of microbial autolysis. The main question that needs to be answered in order to verify the hypothesis is whether oral proteases are able (and to what extent) to lyse/mediate lysis of intestinal microorganisms in situ. Methods based on up-to-date molecular biology techniques to allow investigation of the influence of exogenous proteases on microbial lysis processes in vivo (in the intestines) need to be developed. Research testing of this hypothesis may have an important impact in development of novel preparations for the systemic enzyme therapy.

And more:

Enzymes as effective as a NSAID.

More goodness:

What is also interesting about inflamation and bacterial is that they think that IBD is partly due to the body trying to fight off the good bacteria of the gut.

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Posted 23 August 2006 - 10:41 AM

Bromelain is great. I had to have sinus surgery a few years back, and my doctor suggested I take it for the weeks leading up to my surgery. When I finally had the surgery, I had bruising and swelling on the first day, but they cleared up within a day or so rather than lingering for a week or more.
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