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  • Jefferson Adams
    Jefferson Adams

    Normal Weight or Overweight People Can Also Have Celiac Disease

    Reviewed and edited by a celiac disease expert.

    Celiac.com 05/18/2016 - Common clinical wisdom, and some data, indicate that patients with celiac disease are likely to be underweight. However, data from west suggest that anywhere from 8% to 40% of celiac patients can be overweight or obese.

    What about normal weight? Can people with celiac disease also have normal body weight? A research team recently set out to determine if people with celiac disease can be normal weight. The research team included I Singh, A Agnihotri, A Sharma, AK Verma, P Das, B Thakur, V Sreenivas, SD Gupta, V Ahuja, and GK Makharia.



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    They are variously affiliated with the Department of Gastroenterology and Human Nutrition, the Department of Pathology, the Department of Biostatistics, and the Department of Gastroenterology and Human Nutrition at the All India Institute of Medical Sciences in Ansari Nagar in New Delhi, India.

    To answer that question, a team of researchers recently reviewed data on body mass index (BMI) of patients with celiac disease so they could correlate BMI with other celiac characteristics. For their retrospective study, the team reviewed case records of 210 adolescent and adult celiac patients who were seen at the team's Celiac Disease Clinic.

    To classify BMI as underweight, normal weight, overweight, or obese, they used the Consensus Statement for Diagnosis of Obesity, Abdominal Obesity and the Metabolic Syndrome for Asian Indians for those with age >18 years and revised Indian Association of Pediatrics BMI-for-age charts for those between 12 and 18 years.

    Their results showed that, of 210 patients, 115 patients were normal weight, while 76 patients were underweight, 13 were overweight, and 6 were obese. There was no difference in the proportion of underweight between male and female patients with celiac disease.

    The mean age of underweight patients was similar to those who were normal or overweight. Regardless of weight, there was no difference between any of the patients in terms of average duration of symptoms; frequencies of diarrhea, anorexia, and weakness; anemia; titer of anti-tissue transglutaminase antibody; and severity of villous atrophy in those with underweight or normal weight or overweight.

    Of the celiac disease patients in this clinic, only one third of patients with celiac disease actually had low BMI. More than half had normal BMI, while the rest were either overweight or obese.

    Physicians should not discount the possibility of celiac disease based solely on BMI. Patients with normal and high BMI can also have celiac disease.

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    I was a normal weight person before my diagnosis and was very worried that after I went on the gluten-free diet, my weight would start creeping up. Luckily it didn't. It would be interesting to see what the symptoms of the various weight groups are. My only symptom was anemia - no gastric distress, skin conditions, calcium deficit or mental/emotional aberrations. Despite the anemia I was very active and energetic. I can imagine that those with more severe symptoms might tend to be those who were underweight?

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    I was overweight since early childhood, suffered symptoms since a baby. Gastrointestinal symptoms, predominately, and anemia (doctors said it was because I was a woman) until I became obese in my 40's. I then began having neuro symptoms, and signs of dementia. I had memory loss, forgetting how to add and subtract, or I would be driving and all of a sudden not know where I was, as well as muscle/soft tissue and nerve damage by 48 when I was finally diagnosed. Doctors insinuated I was eating way too much food as the reason for my having celiac but not being underweight. I am finally, after 15 years gluten-free, nearly a normal weight. I believe my body went into starvation mode, shoving everything it could into fat due to malnutrition. I never ate a lot. In fact, I ate little. I was very active, as well, until my body just seemed to begin to completely break down from lack of nutrition. I am glad researchers are finally seeing that not all people will present as underweight. I believe my obesity was actually a symptom of having a celiac caused metabolic problem.

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    I was obese upon diagnosis. I had gained weight for no reason for years--started with 80 pounds in 6 months without explanation, and the other symptoms crept in. Suffered extreme urticaria, incredibly painful and itchy plaque type rashes, dermagraphia on my face, severe migraines, severe malabsorption, would go days forgetting to eat and low caloric intake on days I did eat--no appetite & no hunger, chronic fatigue and insomnia, extreme joint pain, mood swings mimicking bipolar disorder, toward the end (before diagnosis) severe memory issues, very high levels of inflammation evinced by my SED rates, chronic hives, debilitating allergic symptoms year-round to, it seemed, everything, thinning hair... you name it, I was the poster child for celiac symptoms EXCEPT for the weight gain. I was discounted for over a decade by various doctors until I found a doctor who looked at the rest of the symptoms and ordered the biopsy: surprise--positive for celiac. I am gluten free, and TOTALLY symptom free, for 9 years now.

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.


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    Jefferson Adams
    Celiac.com 08/18/2014 - A team of researchers recently set out to better understand the effects of gluten-free diets on obesity.
    The research team included F.L. Soares, R. Matoso de Oliveira, L.G. Teixeira, Z. Menezes, S.S. Pereira, A.C. Alves, N.V. Batista, A.M. de Faria, D.C. Cara, A.V. Ferreira, and J.I. Alvarez-Leite. They are affiliated with the Departamento de Alimentos, Faculdade de Farmácia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais in Belo Horizonte, Brazil.
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     J Nutr Biochem. 2013 Jun;24(6):1105-11. doi: 10.1016/j.jnutbio.2012.08.009. Epub 2012 Dec 17.


    Jefferson Adams
    Celiac.com 11/28/2014 - According to a new study, obesity plays a major part in triggering and prolonging autoimmune diseases, such as celiac disease, Crohn's disease and multiple sclerosis.
    The study appeared recently in Autoimmunity Reviews by Prof. Yehuda Shoenfeld, the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at Tel Aviv University's Sackler Faculty of Medicine and Head of Zabludowicz Center for Autoimmune Diseases at Chaim Sheba Medical Center, Tel Hashomer.
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    For some time now, says Professor Shoenfeld, researchers have been aware of the “negative impact of contributing disease factors, such as infections, smoking, pesticide exposure, lack of vitamins, and the like. But in last five years, a new factor has emerged that cannot be ignored: obesity.”
    According to the World Health Organization, about one-third of the global population is overweight or obese, nearly a dozen autoimmune diseases are now associated with excess weight, which now impact nearly 5-20% of the global population. That is why, according to Shownfeld, it is “critical to investigate obesity's involvement in the pathology of such diseases."
    The main culprit is not fat itself, but adipokines, compounds secreted by fat tissue, which impact numerous physiological functions, including the immune response.
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    "According to our study and the clinical and experimental data reviewed, the involvement of adipokines in the pathogenesis of these autoimmune diseases is clear," says Shoenfeld. "We were able to detail the metabolic and immunological activities of the main adipokines featured in the development and prognosis of several immune-related conditions."
    One of the team’s more interesting findings was that obesity also promotes vitamin D deficiency, which, “once corrected, alleviated paralysis and kidney deterioration associated with the disorder… [and] improved the prognosis and survival of the mice.”
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    Jefferson Adams
    Celiac.com 03/10/2015 - Up to now, celiac disease has been described only in sporadic cases of obesity. A research team recently set out to evaluate retrospectively celiac disease rates in a large group of overweight/obese children and adolescents.
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    All celiac patients immediately began a well-balanced gluten-free diet, and rapid weight loss followed.
    The study shows that celiac rates in overweight/obese children are similar to rates in the general Italian pediatric population, and that those children benefit from proper diagnosis and a healthy gluten-free diet.
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    Journal of Pediatric Gastroenterology & Nutrition: March 2015 - Volume 60 - Issue 3 - p 405–407. doi: 10.1097/MPG.0000000000000656


    Jefferson Adams
    Celiac.com 12/11/2015 - There's an idea, common among lay and medical people alike, that kids with celiac disease are skinny, and that overweight or fat kids can't have celiac disease.
    A new study shows puts this idea to rest, and shows that celiac disease can in fact develop in kids who are overweight or obese. The study was conducted by a team of researchers including T Capriati, R Francavilla, F Ferretti, S Castellaneta, M Ancinelli and A Diamanti.
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    Source:
     European Journal of Clinical Nutrition , (28 October 2015). doi:10.1038/ejcn.2015.169


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