No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Anti-Saccharomyces Cerevisiae Antibodies Common in People with Celiac Disease

Celiac.com 06/26/2007 - In a study published recently in the Scandinavian Journal of Gastroenterology, researchers found that celiac patients commonly have high rates of anti-Saccharomyces cerevisiae antibodies (ASCA). A team of researchers recently set out to assess the frequency anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with celiac disease.

The team was made up of Dorsaf Toumi; Amani MankaÏ; Ramla Belhadj; Leila Ghedira-Besbes; Moncef Jeddi; and Ibtissem Ghedira. They used ELISA to evaluate blood serum for ASCA, IgG and IgA in 238 patients with celiac disease. The team used 80 non-celiac blood donors as a control group. The 238 study subjects were divided into separate groups as follows: 125 untreated celiac patients; 42 celiac patients following a strict gluten-free diet; and 71 celiac patients who did not follow a gluten-free diet.

Celiac Patients Have Significantly Higher IgG and IgA Antibodies

Compared to the control group, the 125 untreated celiacs showed a markedly higher frequency of ASCA (IgG or IgA). 27.2% for untreated against 3.7% for control (p=10-5). Among the 71 patients who did not follow a gluten-free diet the occurrence of ASCA was significantly higher in adults than in children (60% against 26.1%, p=0.004). In the 238 patient study group as a whole, ASCA was substantially higher in adults than in children. 35.4% adults showed positive results compared to 21.1% children (p=0.01). Of the 238 subjects 19% (p=0.001), both children and adult, were positive for ASCA IgG versus 6.3% (p=0.001) for ASCA IgA.

Ads by Google:

ASCA IgG More Common Than ASCA IgA

Overall, ASCA IgG was much more common than ASCA IgA. 19% of children and 33% of adults were positive for ASCA IgG compared to 6.3% of children and 12.5% for ASCA IgA. Of the 42 patients who followed a gluten-free diet, all children and 90.5% of adults were negative for ASCA IgG.
Of the 125 patients with untreated celiac, 20% of children were positive (p=0.01), and 34% of adults were positive. Of those 71 patients who did not comply with a gluten-free diet, 60% of adults and 26.1% of children were positive for ASCA.

The results of the study confirm that patients with celiac disease show a high rate of ASCA. There was no statistical difference between celiacs following a gluten-free diet and those without celiac disease.

Scandinavian Journal of Gastroenterology, Volume 42, Issue 7 2007 , pages 821 - 826

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


We are going to try to make our own this year, but I've seen some great gingerbread houses made out of graham crackers. There are plenty of gluten-free graham crackers out there--Pamela's are nice and sturdy for building! If you make your own, the nice thing is that you don't have to worry whethe...

Symptoms from many illnesses often overlap, so you can not diagnose celiac disease based on them (not to mention that there are over 200 possible symptoms). Best to get a simple blood test. Learn more about testing: http://www.cureceliacdisease.org/screening/

I have eaten the Southwest chicken salad at McDonald's many times, with the grilled chicken and no chips. I have celiac disease, and have no problems with this salad. It's a stand by for me when traveling.

That sense of your thoughts being in a non productive loop is a classic depression symptom I can certainly recognise! The good news is that those patterns you can fall into you can also train yourself to get out of. Some of the best results come from Cognitive Behavioural Therapy or CB...

Hi Lex, First step would be to eliminate celiac. Gluten is well established as the cause of celiac. If you eliminate celiac but still react to gluten foods then it becomes trickier. Non Celiac Gluten sensitivity NCGS is still not universally accepted and there are differing views on whe...