No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Anti-Saccharomyces Cerevisiae Antibodies Common in People with Celiac Disease

Celiac.com 06/26/2007 - In a study published recently in the Scandinavian Journal of Gastroenterology, researchers found that celiac patients commonly have high rates of anti-Saccharomyces cerevisiae antibodies (ASCA). A team of researchers recently set out to assess the frequency anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with celiac disease.

The team was made up of Dorsaf Toumi; Amani MankaÏ; Ramla Belhadj; Leila Ghedira-Besbes; Moncef Jeddi; and Ibtissem Ghedira. They used ELISA to evaluate blood serum for ASCA, IgG and IgA in 238 patients with celiac disease. The team used 80 non-celiac blood donors as a control group. The 238 study subjects were divided into separate groups as follows: 125 untreated celiac patients; 42 celiac patients following a strict gluten-free diet; and 71 celiac patients who did not follow a gluten-free diet.

Celiac Patients Have Significantly Higher IgG and IgA Antibodies

Compared to the control group, the 125 untreated celiacs showed a markedly higher frequency of ASCA (IgG or IgA). 27.2% for untreated against 3.7% for control (p=10-5). Among the 71 patients who did not follow a gluten-free diet the occurrence of ASCA was significantly higher in adults than in children (60% against 26.1%, p=0.004). In the 238 patient study group as a whole, ASCA was substantially higher in adults than in children. 35.4% adults showed positive results compared to 21.1% children (p=0.01). Of the 238 subjects 19% (p=0.001), both children and adult, were positive for ASCA IgG versus 6.3% (p=0.001) for ASCA IgA.

Ads by Google:

ASCA IgG More Common Than ASCA IgA

Overall, ASCA IgG was much more common than ASCA IgA. 19% of children and 33% of adults were positive for ASCA IgG compared to 6.3% of children and 12.5% for ASCA IgA. Of the 42 patients who followed a gluten-free diet, all children and 90.5% of adults were negative for ASCA IgG.
Of the 125 patients with untreated celiac, 20% of children were positive (p=0.01), and 34% of adults were positive. Of those 71 patients who did not comply with a gluten-free diet, 60% of adults and 26.1% of children were positive for ASCA.

The results of the study confirm that patients with celiac disease show a high rate of ASCA. There was no statistical difference between celiacs following a gluten-free diet and those without celiac disease.

Scandinavian Journal of Gastroenterology, Volume 42, Issue 7 2007 , pages 821 - 826

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I used to get migraines. Someone mentioned them as a symptom of celiac disease, and I realized that I had not had one since going gluten-free. Seventeen years and counting...

Migraines can be associated with celiac disease, but the only way to know is to get tested as there are as many as 300 possible symptoms. Learn more: http://www.cureceliacdisease.org/screening/ I wish you well!

I have been a migraine sufferer for 20+ years; since a teenager. Mine have luckily been controlled by Inderal as well as a diet eliminating MSG and artificial sweeteners. However, in May I had a major round of migraines including 4 terrible headaches, aura, nausea, and the works in 4 days...

Welcome. I think that the IgA and IgG tests are ordered as control tests for celiac disease testing. If in range (or close to it), the TTG IgA and the TTG IgG tests are considered to be valid (results accurate). Those tests also let a doctor know if there is an immune system issue. You are ta...

Hi, I'm trying to sort out my 11 year old daughter who has a lot of stomach pain and belching. Her IGG and IGA were both positive 203 and 68 (above 25 positive at this lab) her TTG was negative and her biopsy was negative. What does this mixed result mean? Thanks for you...