No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Anti-Saccharomyces Cerevisiae Antibodies Common in People with Celiac Disease

Celiac.com 06/26/2007 - In a study published recently in the Scandinavian Journal of Gastroenterology, researchers found that celiac patients commonly have high rates of anti-Saccharomyces cerevisiae antibodies (ASCA). A team of researchers recently set out to assess the frequency anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with celiac disease.

The team was made up of Dorsaf Toumi; Amani MankaÏ; Ramla Belhadj; Leila Ghedira-Besbes; Moncef Jeddi; and Ibtissem Ghedira. They used ELISA to evaluate blood serum for ASCA, IgG and IgA in 238 patients with celiac disease. The team used 80 non-celiac blood donors as a control group. The 238 study subjects were divided into separate groups as follows: 125 untreated celiac patients; 42 celiac patients following a strict gluten-free diet; and 71 celiac patients who did not follow a gluten-free diet.

Celiac Patients Have Significantly Higher IgG and IgA Antibodies

Compared to the control group, the 125 untreated celiacs showed a markedly higher frequency of ASCA (IgG or IgA). 27.2% for untreated against 3.7% for control (p=10-5). Among the 71 patients who did not follow a gluten-free diet the occurrence of ASCA was significantly higher in adults than in children (60% against 26.1%, p=0.004). In the 238 patient study group as a whole, ASCA was substantially higher in adults than in children. 35.4% adults showed positive results compared to 21.1% children (p=0.01). Of the 238 subjects 19% (p=0.001), both children and adult, were positive for ASCA IgG versus 6.3% (p=0.001) for ASCA IgA.

Ads by Google:

ASCA IgG More Common Than ASCA IgA

Overall, ASCA IgG was much more common than ASCA IgA. 19% of children and 33% of adults were positive for ASCA IgG compared to 6.3% of children and 12.5% for ASCA IgA. Of the 42 patients who followed a gluten-free diet, all children and 90.5% of adults were negative for ASCA IgG.
Of the 125 patients with untreated celiac, 20% of children were positive (p=0.01), and 34% of adults were positive. Of those 71 patients who did not comply with a gluten-free diet, 60% of adults and 26.1% of children were positive for ASCA.

The results of the study confirm that patients with celiac disease show a high rate of ASCA. There was no statistical difference between celiacs following a gluten-free diet and those without celiac disease.

Scandinavian Journal of Gastroenterology, Volume 42, Issue 7 2007 , pages 821 - 826

Celiac.com welcomes your comments below (registration is NOT required).










Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I haven't seen mine yet, but I got a recommendation from a friend who's son has celiac. When I called the large practice, the scheduler recommended seeing another dr who specializes in celiac. Perhaps ask around?

Thank you very much for your replys! What do you think about getting tested for candida? I was rx d several Anti biotic when this all started!

That ad made me cry. It was so beautiful! I still feel like a sad child sometimes when I go somewhere and there's nothing I can eat. My extended family does not understand at all, and I always have to bring my own food. I know lots of people have to do this too, but sometimes I feel like a...

Hi Christiana, thanks for the reply. I am both interested in the outcome of this story for curiousity and for how it relates a bit to me, Is your pain and pressure similar to the feeling of all your insides about to slide out onto the ground? It is similar to carrying a baby in the third tr...

In comes SIBO Girl to join Captain NCGS One other thought: have you looked at the possibility of having small intestine bacterial overgrowth (SIBO)? The pain you are feeling may be related to bloating pressure, which, if it is caused by SIBO, would continue after the removal of gluten be...