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Study Clarifies Risk Levels for Development of Celiac Disease in Children with Type-1 Diabetes

Celiac.com 07/10/2007 - Studies have shown children with Type 1 diabetes to have a greater risk of developing celiac disease. A study published recently in Diabetes Care shows that people with celiac disease who follow a strict gluten-free diet frequently have inferior body composition and nutritional uptake compared to healthy people without celiac disease.

Faced with a shortage of solid data on the exact nature of the levels at which children with type 1 diabetes are at risk for developing celiac disease, a Swedish research team set out to review the Swedish national inpatient registry for the years 1964 to 2003. The research team was made up of Anders Ekbom, Michael Fored, Jonas F. Ludvigsson, Johnny Ludvigsson, Nders Ekbom, Ola Ole, & Scott M. Montgomery. They looked at data for patients with celiac disease who are following a strict gluten-free diet, and who were in full clinical, biochemical, and histological remission. They looked at data from 45,680 patients. Children with a one year follow-up after entering the study were added to the final results.

Celiac Disease in Children Linked to Type-1 Diabetes

The results showed that children with celiac disease face an increased risk of developing type 1 diabetes before the age of 20 (hazard ratio 2.4 [95% CI 1.9 –3.0], P 0.001). Children with celiac disease also faced an increased risk of ketaocidosis or diabetic coma before the age of 20 (2.3 [1.4 –3.9], P 0.001).

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This increase showed up without regard to the age at diagnosis [those diagnosed between 0 and 2 (2.2 [1.7–2.9], P 0.001) or 3 and 20 (3.4 [1.9 – 6.1], P 0.001) years of age.]

Given that 95% of individuals with celiac disease are HLA-DQ2 positive, these increased risk levels were comparatively low, though still significant.

Diabetes Care. 2006 Nov;29(11):2483-8.

health writer who lives in San Francisco and is a frequent author of articles for Celiac.com.

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Just watch out. I just went to the expo in Schaumburg, IL, and ended up getting glutened. I realized afterward that I ate all these samples thinking they were gluten free, and they weren't. One company was advertising some sugar, and had made some cake, but then I realized.... How do I know if this contains any other ingredients that might have gluten? Did they make it with a blender or utensils that had gluten contamination? Makes me realize the only safe things would be packaged giveaways with gluten free labeling. My fault for not thinking things through. It was just too exciting thinking i could try it all and enjoy without worry.

No fasting required for a celiac blood test unless they were checking your blood glucose levels during the same blood draw.

I wish! I got the flu this winter as well as a couple of colds. I do have 3 lids, the youngest in preschool, so there's always a lot of germs around. Lol

Hey again ? It's a start, but I so wish they'd done the whole panel. Some of us, myself included, test negative to the TTG-IgA. I was positive on the DGP only. I wonder if your insurance will only cover those 2? Regardless, get them done as soon as you can! Do you have a walk in lab where you live? If so, go tomorrow. Then you'll be a step closer to getting answers. Good luck and keep us posted!

I totally agree...this board is awesome! The people on here have been there for me through everything and it has helped so much! I don't think antihistamines would affect the test at all. I take an antihistamine daily as well for horrendous allergies.