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Response to NY Times Article: Confirming a Diagnosis of Celiac Disease
I wrote this response below to address a recent New York Times article: Confirming a Diagnosis of Celiac Disease.
Celiac.com 01/13/2010 - The problem with current diagnosis criteria for celiac disease is that it takes a certain degree of damage to intestinal villi in order to get a formal diagnosis. Since celiac disease with villi damage are just one manifestation of a much broader and more widespread problem--gluten sensitivity--many people who could still develop serious health problems if they continue to eat gluten, will go undiagnosed under the current definition of celiac disease.
The reality of gluten sensitivity is that around 7 to 12% of the US population test positive for antibodies which are an indicator that their immune system is mounting a response to gliadin, the part of gluten that causes the reaction in those who are sensitive. Many of these people may never get flattened villi, however, many may end up with other conditions that are triggered by gluten exposure in sensitive individuals, for example nerve damage (ataxia), liver problems, diabetes, thyroid issues, etc..
In the past 10 years the diagnostic criteria for celiac disease have been changed significantly to include various degrees of villi damage (Marsh Criteria), and as a result, more people are now being properly diagnosed. In the next 10 years I predict that blood tests alone will replace the use of all biopsy results to diagnose celiac disease, as they are a far more sensitive indicator of gluten sensitivity. Once this happens we will finally reach a point where those affected can be properly treated and avoid the risk of the many disorders that have been associated with sensitive individuals who eat gluten, some of which are described here.
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Antireticulin Antibodies Obsolete as Test for Celiac Disease
A recent study of celiac screening methods shows that testing for antireticulin antibodies (ARA) in patients with celiac disease is obsolete.... [READ MORE]
Barley Enzymes Effectively Digest Gluten in Rats
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New Human Anti-tTG type IgA Test Kit is Highly Sensitive and Specific for the Detection of Celiac Disease
Below is an
abstract of yet another study that supports the use of human anti-tTG
type IgA serological tests to accurately diagnose celiac disease:
Alimentary Pharmacology & Therapeutics
Volume 17 Issue 11 Page 1415 - June 2003
Antibodies to human recombinant tissue transglutaminase may detect coeliac
disease patients undiagnosed by endomysial antibodies
N.... [READ MORE]
Pathology of Celiac Disease
The following was taken from THE SPRUE-NIK
PRESS, September 1995.... [READ MORE]
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
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