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Encouraging New Celiac Disease Drug 03/12/2010 - According to the National Institutes of Health, approximately 3 million Americans suffer from celiac disease. Characterized by small intestinal inflammation, intestinal injury and intolerance to gluten, celiac is  a genetic T-cell mediated auto-immune disease. Those diagnosed with celiac disease know that the only cure is an entirely gluten-free diet for life.  When left untreated, celiac can manifest into life-threatening illnesses such as, heart disease, osteoporosis, and cancer. However, modern science is now presenting us with an alternative to suffering needlessly, and it comes in the shape of a little non-assuming pill called Larazotide Acetate.

While celiac disease affects 1 in 133 people, those numbers do not take into account the thousands of other people who are impacted from gluten intolerance and gluten related allergies. Gluten comes in many disguises but can be found primarily in wheat, rye, and barley. Since the Food and Drug Administration has not yet mandated gluten disclosures on labels, many foods are contaminated with hidden gluten. People that suffer from the inability to digest gluten are extremely limited when it comes to dining, and often find themselves eating alone or bringing their own gluten-free food to social events.

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Eating a microscopic amount of gluten, for many gluten sensitive sufferers,  frequently leads to varying degrees of sicknesses including, diarrhea, vomiting, rashes, and insomnia. Some people are more sensitive than others, and those most sensitive to gluten cannot eat at many restaurants due to the chance of cross contamination. Much like a peanut allergy, those gluten sensitive can  get sick from eating gluten-free food that was cooked in the same kitchen as gluten food by means of contamination, or simply from receiving a kiss from a loved one that has traces of gluten on their mouth.

With so many unsavory reactions to food, the medical community has been attempting to devise a drug for celiacs that allows them to safely digest gluten. A new drug called Larazotide Acetate, has been called 'revolutionary' to the celiac and gluten sensitive community, and may be what celiacs need to live a more normal life. While it is not a cure, Larazotide Acetate has been proven in clinical trials to greatly reduce the negative reactions celiacs have with gluten. Clinical test patients displayed a decrease  in  intestinal damage, from 50% to 15%, when ingesting gluten after taking Larazotide Acetate.

Larazotide Acetate may very well be the new breakthrough drug of the decade. It offers celiacs and others with gluten sensitivities, the freedom to eat out at restaurants, or go to a friends house for dinner without the physiological and emotional stress that can accrue from worrying about, and getting sick from gluten contaminated food.

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8 Responses:

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said this on
01 Apr 2010 12:39:24 AM PST
I heard about these trials last year (for Larazotide Acetate) and checked out the actual clinical trial site. Well, the disturbing fact about the trials are that ALL the participants were REQUIRED to adhere to a gluten free diet to begin with. Now how do they know the drug itself is actually working if the participants are already gluten free? Wouldn't they already be decreasing the damage to their intestines by being gf alone?! It would automatically throw the testing results off. I wrote and confronted the doctors about this and heard nothing back from them. I'm sure they wished that no one would bring that fact up, which is why my email was left unanswered. I found the trial to be faulty and untrustworthy by that alone.

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said this on
01 Apr 2010 4:56:59 PM PST
I gather that the reason for the gluten free diet is that they try and get the 'test subject' as healthy as possible and then try and test the effects of gluten on them. Think about your comments for a moment will you?
If you know much about coeliac disease then you should know that the damage occurs very quickly with a very small exposure and takes 3 to 6 months in an adult to repair.

What would be the point of having a damaged person take the drug - its not a cure - just a potential way of blocking some of the reaction to gluten (which is a pretty good start if you ask me).

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said this on
02 Feb 2013 5:11:51 AM PST
Couldn't agree more Robert. I think she miss understands the reason for the pill. I'm sure if she thought it through it would make sense.

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said this on
08 Aug 2011 11:39:11 AM PST
Can't wait for this to come on the market. I don't mind eating gluten free (my 9 year old celiac daughter is having a harder time). I just see the drug as a fail safe for cross -contamination and such rather than a cure. I hope it's out soon!

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said this on
21 Nov 2011 2:00:10 PM PST
I'd prefer some research on the other problems that come with having a destroyed small intestine. They are many but few have been researched. I was diagnosed with "ovarian failure" 6 years before I was diagnosed with celiac disease. Too late for me to conceive now.
How about some research on celiac intestines and hormones? I think that would be more important than being able to eat pizza again.

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said this on
23 Jan 2012 11:53:39 AM PST
Yes they are testing a drug to block Zonulin which MAY be responsible for the damage in the small intestines. But look up the research - the researchers admit they don't know how it all works yet and they want to make a drug that will block this protein. A reduction of 50% to 15% damage is still DAMAGE! I am sorry but this will not work...when are we going to wake up from this perception that a stupid pill will fix everything - it doesn't! I agree it can be hard sometimes when you go out to eat and I had to learn to cook differently - But I also learned a lot about good nutrition and lets face it the whole population consumes too much wheat!

Think about this - the body makes Zonulin for a reason but people with CD make too much - so they want to totally block it - does that sound like a good idea?

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said this on
07 Jun 2012 3:27:22 PM PST
If this drug is just going to reduce reactions to gluten, yet you are still putting gluten into your body and you are allergic to it, how is this going to help? It seems to me that you will still be damaging your body but you won't get the reactions.

ali asghar fozouni
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said this on
08 Aug 2012 8:54:34 AM PST
I'm from Iran. I am 38 years old and I have celiac disease. Would you please help me and show me the drugs treatment?

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