No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Diagnostic Performance of IgG Anti-deamidated Gliadin Peptide Antibody Assays is Comparable to IgA Anti-tTG in Celiac Disease

Celiac.com 03/25/2010 - A team of researchers recently set out to compare the diagnostic performance of IgG anti-deamidated gliadin peptide antibody assays against IgA anti-tTG in celiac disease. The team included P. Vermeersch, K. Geboes, G. Mariën, I. Hoffman, M. Hiele, X. Bossuyt, all associated with the department of Laboratory Medicine, Immunology of University Hospitals at the Catholic University of Leuven, Belgium.

Using IgG anti-deamidated gliadin peptide antibody assays to test for celiac disease is more sensitive and more specific for celiac disease than detection of IgG antibodies against native gliadin. The team compared assessed the technical performance and accuracy (sensitivity and specificity) of commercial IgG anti-DGP assays from Euroimmun, Inova, Phadia and The Binding Site against other serologic assays for celiac disease, such as 3IgA and 2IgG anti-tTG assays, 1IgA and 1IgG anti-gliadin assay, 1IgA anti-DGP assay.

For the study, they tested 86 patients with clinically proven celiac disease and 741 healthy control subjects. Technical performance of IgG anti-DGP assays as gauged by linearity, interference and imprecision, was within acceptable levels. IgG anti-DGP assay sensitivity ranged between 76.7% and 83.7% at the manufacturer's recommended cut-off, and between 74.4% and 84.9% at a cut-off that corresponded to a 98% specificity level. Specificity ranged between 97.3% and 99.3%.

Ads by Google:

The diagnostic accuracy of the IgG anti-DGP assays was comparable to the diagnostic accuracy of the IgA anti-tTG assays. IgG anti-DGP assays showed significantly better than sensitivity than the IgG anti-tTG assays (p<0.05) and and significantly better specificity than IgA and IgG anti-gliadin assays (p<0.05).

The four IgG anti-DGP assays all performed within acceptable limits, and diagnosed celiac disease with comparable accuracy as did the three IgA anti-tTG assays.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I ate there July 23 2017, had cheeseburger with gluten free bun (charged extra 2 dollars) which tasted very good. dressed burger with tomato, pickles and onion and even mayo with no unpleasant affects. I appreciated the choice of gluten-free bun. Also, the young man serving us asked if I wanted...

I think you will find that aromatherapy is safe. I have had the same thing when having facials many, many times over 12 years gluten free and have never, ever had a problem. I have never found any aromatherapy that contained gluten. I am a very sensitive, diagnosed Celiac. As far as lotion is c...

There is a lot of information on site about living with Celiac disease. A good idea is to take a look at the "coping with" section and the "newbie info 101" thread. There is a lot of good information about cross contamination and proper nutrition.

Sorry to hear about your no meat, Ennis. It sucks his celiac disease messes with people in different ways. Matt I was living on sweet potatoes but now they bloat me, which is odd. Avocado's would be to much fat, I think. I'm three weeks in today, and the past few days my C has improved....

I hope you don't have to wait too long for the results. A false negative is always possible since we have a lot of intestine but it sounds like you have a good doctor who took lots of biopsies. Since she had a high positive it would be a good idea for her to do the diet strictly for a few months...