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Breastmilk, Baby Formula, and Genetic Factors Likely Influence Celiac Disease Risk 09/09/2011 - A team of researchers recently set out to assess the effects of milk-feeding behavior and the HLA-DQ genotype on intestinal colonization of Bacteroides species in infants with a risk of developing celiac disease.

The research team included E. Sánchez, G. De Palma, A. Capilla, E. Nova, T. Pozo, G. Castillejo, V. Varea, A. Marcos, J. A. Garrote, I. Polanco, A. López, C. Ribes-Koninckx, M. D. García-Novo, C. Calvo, L. Ortigosa, F. Palau, and Y. Sanz.

They are affiliated with the Ecofisiología Microbiana y Nutrición, Instituto de Agroquímica y Tecnología de Alimentos (CSIC) in Valencia, Spain.

appl-env-microbiology--sept-2011The team studied 75 full-term newborns with at least one first-degree relative who suffered from celiac disease. They classified the newborns according to milk-feeding practice (breast-fed or formula fed) and HLA-DQ genotype, which indicates high or low genetic risk.

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The team used PCR and denaturing gradient gel electrophoresis (DGGE) to analyze stools at 7 days, 1 month, and 4 months. They found that formula-fed infants showed greater Bacteroides species diversity than did breast-fed infants.  Breast-fed infants showed a higher prevalence of Bacteroides uniformis at 1 and 4 months of age, while formula-fed infants had a higher prevalence of B. intestinalis at all sampling times, of B. caccae at 7 days and 4 months, and of B. plebeius at 4 months.

Infants with low genetic risk showed greater colonization of B. ovatus, B. plebeius, and B. uniformis, while those with high genetic risk showed a greater colonization of B. vulgatus.

Among breast-fed infants, those with low genetic risk had greater colonization of B. uniformis than those with high genetic risk, who showed higher rates of B. vulgatus.

Among formula-fed infants, the prevalence of B. ovatus and B. plebeius was increased in those with low genetic risk, while the presence of B. vulgatus was greater in those with high genetic risk.

The results indicate that both the type of milk feeding and the HLA-DQ genotype influence the types of Bacteroides that colonize in the intestinal tract, and possibly also influence risk for developing celiac disease.

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13 Responses:

Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
12 Sep 2011 12:05:47 PM PDT
I've read this twice and I still don't understand the results.

Rating: ratingfullratingfullratingemptyratingemptyratingempty Unrated
said this on
12 Sep 2011 1:48:45 PM PDT
So what are you saying? Don't breast feed if you have Celiac? These articles are amazing. Give to us so we can understand

Mary M
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said this on
12 Sep 2011 5:12:49 PM PDT
So what's the conclusion?

Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
13 Sep 2011 5:11:47 PM PDT
What are the results? I do not understand your article! Please let us know!

Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
13 Sep 2011 7:30:52 PM PDT
This article does not make it clear whether a high diversity of bacteriodes is a good or bad thing, so it is impossible for the lay person to understand the implications of the results.

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said this on
20 Sep 2011 5:32:37 PM PDT
Agreed - please explain further - I don't understand if it is good or bad to breastfeed if you are trying to prevent celiac.

Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
29 Sep 2011 10:51:23 AM PDT
When writing an article for others to read, remember to explain your findings in a non scientific manner. This article does not make sense to it's readers, and can create confusion. Especially to those that are struggling with breastfeeding. Regardless of what it does or does not say- I will continue to breastfeed my baby, because I don't think that God's creation and design for mother's to feed their babies has any better way.

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said this on
24 Apr 2012 9:02:11 AM PDT
Thought it was just me, but evidently I'm not the only person who wasted my time reading this poorly worded article. Still have no clue what the findings really meant, since there was no conclusion.

Rating: ratingfullratingfullratingemptyratingemptyratingempty Unrated
said this on
23 May 2012 12:26:00 PM PDT
What? I did not understand. Can you put it in English for the rest of us so we can understand it?

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said this on
25 May 2012 2:55:28 PM PDT
What it is saying is that the types of bacteria were more diverse in formula fed infants at first, but the infants that were genetically predisposed in each group had higher B. vulgatus regardless of type of milk.

Andrew jones
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said this on
10 Nov 2013 7:57:33 AM PDT
Research is still pending. High vs low diversity in the gut and celiac disease are not yet known. The article shows a pattern and that pattern has to be investigated further. Too soon for conclusions.

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said this on
25 Jan 2014 3:42:45 PM PDT
So the conclusion is that breast milk is better but you don't want to offend your sponsors? Because I sort of got that from the article about pushback on GMO wheat as a cause.

Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
29 Jan 2014 11:21:23 PM PDT
So the conclusion - breast milk is protective. Breast milk causes less diverse bacteria population in gastrointestinal tract, predominantly comprising of B. uniformis and therefore provides protection against the celiac disease as compared to formula fed infants.

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