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Drug May Lower Gluten Toxicity in Patients with Celiac Disease

Celiac.com 04/18/2012 - Biopharmaceutical development company, BioLineRx, has announced results from pre-clinical trials which show that their compound, BL-7010, an orally available treatment for celiac disease, reduces the toxic effects of gluten in patients with celiac disease.

Photo: CC - Jeremy BronsonThe findings, which appear in the February issue of Gastroenterology, show that BL-7010, which was previously labeled P(HEMA-co-SS, lowers gluten toxicity by  reducing the body's digestion of wheat gluten.

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The findings also show that BL-7010 also improves the immune response to gluten in rodents, as well as preventing gluten-induced pathological damage to the small intestine.

Furthermore, they note that BL-7010 is not absorbed systemically, indicating that its gluten-neutralizing effects are likely safe. These data demonstrate BL-7010's therapeutic potential for reducing or blocking gluten-induced disorders in humans with celiac disease.

Because it can be difficult to maintain a life-long, strict, gluten-free diet, the fact that BL-7010 may attenuate the immune response to gluten and reduce subsequent damage to the small intestine, suggests that this drug, or others like it may be useful in improving quality of life for millions of celiac disease patients.

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5 Responses:

 
rct
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
18 Apr 2012 11:37:25 AM PDT
Very useful website.

 
Joanie
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
23 Apr 2012 3:59:17 PM PDT
How do you get that BL 7010?

 
Malin
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
27 Apr 2012 1:47:15 AM PDT
In the article it is made clear that BL7010 might be developed into an interesting drug in the future but that the effect has been seen in pre-clinical trials. There are no evidence (the optimist would add "yet" to this sentence) that BL7010 has a good enough effect to be useful for celiac patients.

 
Diane
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
28 Apr 2012 10:52:06 AM PDT
Interesting, however, I don't know where to get this product. I would use this BL 7010 as I have very violent reactions to gluten.

 
Roberta
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
30 Apr 2012 11:43:15 AM PDT
Can't wait for this, or similar products to help us live more normally! I'm tired of being the "pain-in-the-butt" person every time I go out to eat!




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