22905 People with Celiac Disease Face Higher Risk of Psoriasis - Celiac.com
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People with Celiac Disease Face Higher Risk of Psoriasis

Celiac.com 05/19/2012 - Because a number of past studies examining the connection between celiac disease and psoriasis have had contradictory findings, researchers wanted to get a better idea of the actual risk of psoriasis in patients with biopsy-verified celiac disease.

Photo: CC - mysianaThe researchers were J.F. Ludvigsson, B. Lindelöf, F. Zingone, and C. Ciacci, with the Department of Pediatrics at Sweden's Örebro University Hospital.

For their study, they used data from 28 pathology departments in Sweden to identified individuals with celiac disease diagnosed between 1969 and 2008. They found 28,958 patients with Marsh 3 villous atrophy.

They then used Cox regression to compare those celiac disease patients with 143,910 sex- and age-matched control subjects, and to assess the risk of psoriasis.

They found that celiac disease was a risk factor for future psoriasis (hazard ratio (HR) = 1.72; 95% confidence interval (CI) = 1.54-1.92. They found that, during follow-up, 401 individuals with celiac disease and 1,139 controls were diagnosed with psoriasis.

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They found that the absolute risk of future psoriasis in patients with celiac disease was 135 per 100,000 person-years, with an excess risk of 57 cases per 100,000 person years.

Overall, 42% of the cases of psoriasis in patients with celiac disease could be attributed to celiac disease. Moreover, in children the team saw a strong association between celiac disease and psoriasis (HR = 2.05; 95% CI = 1.62-2.60).

Their results show that the connection between celiac disease and psoriasis seems to be far more than coincidental, as we also found a positive association between celiac disease and psoriasis before celiac diagnosis, with an odds ratio of 1.91; 95% CI = 1.58-2.31).

They conclude that individuals with celiac disease do, in fact, face an increased risk of psoriasis both before and after celiac diagnosis.


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6 Responses:

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said this on
28 May 2012 6:07:44 PM PDT
Not exactly news to me. From the age of 5 until my mid-50s I suffered from several large patches of plaque psoriasis on my major joints, the palms of my hands, and the soles of my feet which would often crack open and bleed. I had been to several doctors about it, but none of their treatments brought any relief, and a few made it even worse, leading to secondary skin lesions and infections. Within a week of going gluten-free, the patches began to fade, and within a few months, only a tiny dime-sized patch remained on my right knee. Today, within hours of accidental gluten exposure, dry white blisters form on the palms of my hands and the skin takes several weeks to dry, crack, and eventually sluff-off. Curiously, none of my doctors seem to think this is a significant indicator of gluten intolerance. I'm glad to see the world is finally beginning to notice.

Sarah S
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said this on
28 May 2012 8:46:12 PM PDT
My sister is 33 and recently found out she has celiac disease. She has suffered from severe psoriasis since she was 9. We had always attributed it to stress. It makes sense that it would have actually come from her celiac disease though. Her gluten-free diet is helping.

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said this on
29 May 2012 8:13:39 AM PDT
My eczema/psoriasis improved dramatically after going on a gluten-free diet. I always thought it was a coincidence. Very interesting that it is not. Since I don't have typical gastrointestinal symptoms for my Celiac, just vitamin deficiencies, I will watch the psoriasis symptoms as a guide for when I've accidentally eaten something with gluten.

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said this on
11 Jun 2012 5:03:28 PM PDT
As an undiagnosed celiac in December, 1995, I scratched my knee which led to a variety of nasty skin rashes, one of which was diagnosed as psoriasis. I had colon cancer in March, 1996. Since it was not dermatitis herpepiformis, local celiac disease goop and doctors said it was not celiac disease related. I was sure that it was.

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said this on
26 Jul 2012 5:44:06 PM PDT
I also had weird rashes. I would be in the shower and get a burning sensation on my leg. When I dried off it would stop burning and the next day it looked like prickly heat and it would come back in the shower at times in the same spot. I suffered from reflux for years, developed Graves disease (thyroid), osteoporosis, my gall bladder stopped working and 3 years after it was removed I got stomach bloating and extreme gas and foul bowels. I got a new gastroenterologist that did all blood work for celiac diseaes, hydrogen breath tests for parasites and food intolerances. I had an endoscopy and colonoscopy. All showed nothing, except I had one gene positive for celiac diseaes and one negative. I cannot have any dairy, soy or gluten based on my own body's feeling sick when I do. The rashes have gone, and for the most part I feel better, though I am still tired at times. Celiac diagnosis is very hard to get unless you have the flattened villi or the blistery rash or both genes positive. There still may be other genes they are unaware of though. You must be your own doctor.

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said this on
21 Dec 2012 11:48:47 AM PDT
Interesting. I have had psoriasis for 50 years, and not one doctor has ever related it to celiac disease, yet my symptoms for celiac seem to match what I'm reading in this report. I will try a gluten-free diet for 2 weeks to pinpoint a problem with food, celiac and psoriasis. Then I will see my doctor.

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I've been seeing my dr for a few weeks now about my stomach issues. We've ruled out the gallbladder and h-pylori and today I had the celiac blood tests done. From the reading I've done the past two days, it seems to me that it's highly likely that I have it. I've had digestive issues for years, but they've gotten progressively worse over the past 6 months or so. Pain and nausea when eating, bloat, eternal constipation, dh rash, at it's worse, tight cramp-like pain in a fist under my sternum, radiating through my back and around my right side keeping me up at night. Also heartburn/reflux and trouble swallowing, etc. Anyway, about 2 months ago, I needed a change. I didn't go to the dr immediately because it seemed pointless. (I've mentioned stomach ache when eating to drs before and been blown off.) So, I started the Whole30 elimination diet (takes out soy, grains, dairy, peanuts, and leaves you basically eating meat & veggies). Figured it would show me what I needed to take out of my diet and hopefully feel better. It worked- I felt great! And it seems that grains and gluten are my biggest offenders. But, now I've been off gluten prior to celiac testing. It's been 7 weeks. After 4 weeks I tested steal cut oats, that I later found out were probably glutened. And then nothing until yesterday. Yesterday I had 2 pieces of bread and a muffin and today I had two pieces of bread and then the blood test. Is this going to be enough to show up on the tests? My dr said that it would probably show up, since I had some yesterday and today and was currently having symptoms. But, google seems to say that I should be glutened for 2 wks straight before testing. Has anyone tested positive after just a little gluten? If it's negative should I insist on doing it again after weeks back on gluten? I feel awful, but do want clear answers. Obviously, gluten's not going to be a part of my life any more either way.

So just to clarify had not consumed any gluten for about 4 days before testing. I was assured by my allergist that it wouldn't affect the test. But what was alarming was that she retested my food allergies (my most recent reaction was two weeks ago) and every food allergy I have came back negative. I don't understand how that is possible. These food allergies developed when I was 20 and I am almost 24 now.

Thanks! You too! I have learned from this experience to take charge of my own health. It's nice at least that we can try the gluten-free treatment without a firm diagnosis or a doctor confirming the disease. I've also felt some of the gluten withdrawal symptoms, and my stomach pain ebbs and flows, but I'm determined to stick with the gluten-free diet to see what a difference it makes. Gemini, thank you! This was really validating and useful for me to hear. I've felt so confused through this process and just want some answers. If the biopsy results do come back negative, I'm going to follow your advice and do the gluten-free diet with repeat blood testing after a while. If they come back positive, well, then I'll have my answer. I'm supposed to get them back next week.

I have celiac and eosinaphalic esophagitis. I was put on a steroid inhaler recently. I use it like an inhaler but swallow the air instead of breathing it in. You may want to look into EOE and it's relationship to celiac. Just a thought. My swallowing and celiac seem to be related.

You have eat gluten every single day until after testing. And the celiac blood test is supposed to be done as well.