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How Old Are the Genetic Factors that Leave us at Risk for Celiac Disease?

Celiac.com 06/24/2013 - Researchers don't know much about the genetic history of celiac disease. They know especially little about the age of specific gene sequences that leave people at risk for developing celiac disease.

Photo: CC--Dave PearsonA recent case study provides a small bit of information about that question. The information was gathered by a team of researchers looking into the case of a young, first century AD woman, found in the archaeological site of Cosa. The woman's skeleton showed clinical signs of malnutrition, such as short height, osteoporosis, dental enamel hypoplasia and cribra orbitalia, indirect sign of anemia, all strongly suggestive for celiac disease.

The research team included G. Gasbarrini, O. Rickards, C. Martínez-Labarga, E. Pacciani, F. Chilleri, L. Laterza, G. Marangi, F. Scaldaferri, and A. Gasbarrini. They are affiliated with the Ricerca in Medicina Foundation NGO, Falcone and Borsellino Gallery, in Bologna, Italy.

However, initial inspection of the woman's bones did not provide answers about the genetics that might confirm that these traits were, in fact, associated directly with celiac disease.

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To do that, the team needed to examine her human leukocyte antigen (HLA) class II polymorphism. That required extracting DNA from a bone sample and a tooth and genotyping HLA using three HLA-tagging single nucleotide polymorphisms for DQ8, DQ2.2 and DQ2.5, specifically associated to celiac disease.

The results showed that the woman did in fact carry HLA DQ 2.5, the haplotype associated to the highest risk of celiac disease. This is the first time that researcher have documented the presence of a celiac-associated HLA haplotype in an archaeological specimen.

The results show that the genetic markers associated with high risk of celiac disease are at least a couple of thousand years old.

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2 Responses:

 
Team Sorbeo
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said this on
24 Jun 2013 6:16:45 PM PDT
Celiac disease is only recently coming into awareness, but it's interesting that the genetic factors are so old.

 
Jacob
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
03 Jul 2013 4:57:02 PM PDT
For the past 100 years, doctors have pushed to the side as having IBS.




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This is stupid. The nuns at Clyde, Missouri make gluten safe hosts. 17 ppm. Well under the 20 ppm threshold. I consume them safely here in Omaha every week.

When I was diagnosed, I told both kids they will have to be tested. They don't know it will be happening sooner rather than later.

Tell him asap to expect to get blood drawn next week or whenever the appt. is. My boys never like surprise medical exams!

Have him read about the disease and the multitude of repercussions that occur from gluten consumption that have nothing to do with "classic stomach" issues. Not following a strict gluten free diet can lead to terrible diseases because your body will be so weak and damaged. When my son was diagnos...

When I get glutened, I cough. Loud. for 20-30 minutes. Once people hear that, they take it seriously. Refer your son to the newbie thread. If he still doesn't get it, kick him in the posterior. Hard!