Celiac Disease and Gluten-Free Diet Support
- Questions? Join our forum: Nearly 1 MILLION POSTS, and over 62,000 MEMBERS!
Follow / Share
|Get Email Alerts|
- Safe Gluten-Free Food List (Safe Ingredients)
- Unsafe Gluten-Free Food List (Unsafe Ingredients)
- Gluten-Free Alcoholic Beverages
- Celiac Disease Symptoms
- The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free
- Interpretation of Celiac Disease Blood Test Results
- Is Buckwheat Flour Really Gluten-Free?
Are Industrial Food Additives to Blame for Soaring Rates of Autoimmune Disease?
Celiac.com 01/19/2016 - Cases of autoimmune diseases are on the rise, and mirror the expansion of industrial food processing and increased use of food additives. The intestinal epithelial barrier, with its intercellular tight junction, controls the balance between tolerance and immunity to non-self-antigens.
Recently, a team of researchers set out to assess the role of tight junction dysfunction in the pathogenesis of autoimmune disease.
Researchers Aaron Lerner and Torsten Matthias are associated with the Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B, Rappaport School of Medicine, Technion-Israel Institute of Technology, Michal in Haifa, Israel, and the Aesku Kipp Institute in Wendelsheim, Germany.
Numerous common industrial food additives increase tight junction leakage. These include glucose, salt, emulsifiers, organic solvents, gluten, microbial transglutaminase, and nanoparticles, widely and increasingly used in industrial food production.
According to manufacturers, these additives improve food quality. However, all of the aforementioned additives increase intestinal permeability by breaching the integrity of tight junction paracellular transfer.
So why is this a problem?
Well, it turns out that tight junction dysfunction is common in multiple autoimmune diseases, and the central part played by the tight junction in autoimmune diseases development is widely described.
The researchers hypothesize that commonly used industrial food additives undermine human epithelial barrier function, which increases intestinal permeability through the opened tight junction, resulting in entry of foreign immunogenic antigens and activation of the autoimmune cascade, and the development of autoimmune conditions, such as celiac disease.
The team is calling for additional research on the connections between food additives exposure, intestinal permeability, and autoimmunity interplay to expand our knowledge of the common mechanisms associated with autoimmune progression.
Celiac.com welcomes your comments below (registration is NOT required).
Is Wheat Breeding Really Driving Higher Rates of Celiac Disease?
Increased rates of celiac disease over the last fifty years are not linked to wheat breeding for higher gluten content, but are more likely a result of increased per capita consumption of wheat flour and vital glutens, says a scientist working with the US Department of Agriculture (USDA).... [READ MORE]
More Evidence Links Gut Bacteria to Celiac Disease
Previously, the possible link between gut bacteria and celiac disease has been discussed in "Do Vitamin D Deficiency, Gut Bacteria, and Gluten Combine in Infancy to Cause Celiac Disease?" A 5-year European study, DIABIMMUNE, is currently underway focusing on some 7000 children, from birth, investigating the development of intestinal bacterial flora and its influence on the development of the human immune system and autoimmune disease, including celiac disease.... [READ MORE]
Unglued: The Sticky Truth About Wheat, Dairy, Corn and Soy
Approximately 70% of all American calories come from a combination of the following four foods: wheat, dairy, soy and corn - assuming, that is, we exclude calories from sugar.... [READ MORE]
Wheat: A New Option for Carry-Out Containers
... [READ MORE]
Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.
He is a member of both the National Writers Union, the International Federation of Journalists, and covers San Francisco Health News for Examiner.com.View all articles by Jefferson Adams
In Celiac.com's Forum Now:
Celiac.com Celiac Disease & Gluten-Free Diet Forum - All Activity