No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Ethnic Differences Seen in Celiac Disease Autoimmunity in Childhood


Photo: CC--Art Around

Celiac.com 03/13/2017 - A team of researchers recently set out to determine whether there might exist ethnic differences in celiac disease autoimmunity in children at 6 years of age, and if present, to assess how these differences may be explained by known sociodemographic and environmental factors.

The research team included Michelle A E Jansen, Sytske A Beth, Diana van den Heuvel, Jessica C Kiefte-de Jong, Hein Raat, Vincent W V Jaddoe, Menno C van Zelm, and Henriette A Moll. They are variously affilated with the Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands; the Department of Paediatrics, the Department of Immunology, and the Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands, and with the Department of Public Health, University Medical Center, Rotterdam, the Department of Global Public Health at Leiden University College, The Hague, The Netherlands, and with the Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Australia.

The team embedded their study within a multi-ethnic population-based prospective cohort study of 4442 six-year-old children born between 2002 and 2006.

They used questionnaires to assess information on ethnicity, environmental and lifestyle characteristics. They divided ethnicity into Western, which included Dutch, European, Indonesian, American, Oceanian, and non-Western, which included Turkish, Moroccan, Cape Verdean, Antillean, Surinamese.

The team then used fluorescence enzyme immunoassay to measure serum transglutaminase type 2 antibody (TG2A) levels . They used ELISA to measure serum IgG levels against cytomegalovirus (CMV). They defined TG2A positivity as TG2A ≥7 U/mL, strong TG2A positivity as TG2A ≥10 upper limit normal (70 U/mL).

Ads by Google:

Of the 4,442 children they assessed, just 60, or 1.4%, tested TG2A positive. Of these 60, 31 registered strong positive. In all, 66% of these children were Western, 33% non-Western.

Western ethnicity, high socioeconomic position and daycare attendance were positively associated with strong TG2A positivity (odds ratio (OR) 6.85 (1.62 to 28.8) p

Together, these factors explained up to 47% (−67 to −17; p=0.02) of the ethnic differences in TG2A positivity between Western and non-Western children.

Ethnic differences in children with celiac disease autoimmunity are present in childhood. Socioeconomic position, daycare attendance and CMV seropositivity partly explained these differences, and may serve as targets for prevention strategies for CDA.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


While it could be related to celiac disease or it could be the start of Parkinson?s, it might be a simple palsy. This hand shaking happens in my family. It has for generations. It affects some others in my family differently. They shake their heads. We call it ?Bobble Head Syndrome? , not...

There are lots of reasons for shaking hands. What does the doctor say?

Hello, my mother (67), suffers years of hypofunction of the thyroid gland. Six months ago, celiac disease was diagnosed. She has a diet for about 5 months. She sometimes shakes her hand. We have to worry about Parkinson, or there is a link with celiac disease? My mother is very moving and is...

Is there new legitimate research on this? Please post a link. I have not seen anything that proves that assumption.

The casein in milk is very similar to the gluten protein, and over time the ammune system can react to the casein as though it was gluten. This happens over time, and though you may have been able to consume dairy previously, you may have to avoid it now. Not good to suffer the consequences, it ...