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Why Your Microbiome is the Future of Celiac Disease Treatment

Your own unique microbiome may represent the future of personalized medicine, including customized treatments for celiac disease


Photo: CC--Tszchungwing

Celiac.com 12/25/2017 - In the very near future, your personal microbiome may be the key to creating a customized treatment for celiac disease.

That's because new advances in genome studies are promising to help create a customized, individual approach for treating numerous disorders, including celiac disease. Such individualized treatments may also help to reduce adverse events, and decrease health care costs.

So far, a similar approach for optimizing preventive and therapeutic approaches in cancer using human genome sequencing has proven successful.

Writing in the Mayo Clinic Proceedings, ad team of researches expounded on this approach. The research team included Purna C. Kashyap, Nicholas Chia, PhD, Heidi Nelson, MD, Eran Segal, PhD, and Eran Elinav, MD, PhD. They are variously affiliated with the Enteric Neuroscience Program, Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN; the Department of Surgery, Mayo Clinic, Rochester, MN; the Department of Computer Science at the Weizmann Institute of Science in Rehovot, Israel and with the Department of Immunology, at the Weizmann Institute of Science in Rehovot, Israel.

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Your personal microbiome is the sum total of all the microbes that reside within and upon you, along with all their genetic elements. Using genome sequencing allows doctors to design highly personal, highly focused treatments and therapeutic strategies.

In their review for the Mayo Clinic Proceedings, the team highlights the importance of the microbiome in all aspects of human disease, including pathogenesis, phenotype, prognosis, and treatment response. The microbiome also plays a crucial role as a diagnostic and therapeutic biomarker.

The team's report describes the role to be played by next-generation sequencing in helping to provide precision microbial identification of infectious diseases, and helping to elucidate the nature and function of microbial communities.

Basically, as we further unlock the human genome, we can begin to better understand the role played by the myriad microbes that make up the human microbiome. As we unlock the role of various parts of the microbiome, look for major advances and refinements to diagnosing, treating, and even conquering conditions like celiac disease, and many others. And, with advances coming at breakneck speed, look for this to happen sooner, rather than later.

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3 Responses:

 
Laura
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
03 Jan 2018 7:55:17 AM PST
Domesticated durum wheat has been hybridized with wild diploid grass to make the hexaploid wheats, spelt wheat and bread wheat which have three sets of paired chromosomes (three X as many as in diploid wheat). Recent deliberate selection of alleles has created the ´dwarfing´ trait. Genetic mapping enable breeders recognize crossover events occurring in progeny lines & allow for genetic marker placement. Breeding objectives include high grain yield, good quality, disease and insect resistance and tolerance to abiotic stresses, including mineral, moisture and heat tolerance. However, the human tolerance was "NOT considered", "NOR investigated" prior to the yield being released into market. "Modern" bread wheat varieties have been cross-bred to contain greater amounts of gluten. Ask yourself the following questions: (1) Do you have a 4 chamber stomach that is necessary for digesting grass? (2) Do you believe eating "grasses" is healthy? (3) Do you want to risk developing celiac disease, non-celiac gluten sensitivity, gluten ataxia and dermatitis herpetiformis? (4) Do you want to risk never again having the ability to eat gluten cross-reactors yeast or egg or dairy or and products containing these? It's too late for hundreds of thousands of people world-wide who have developed celiac and gluten related diseases since the 2009 arrival of the "modern" dwarf wheat. The impact on industries: egg and dairy farmers has been financially substantial. (5) Do you ever wonder why the FDA did not required controlled testing of a wheat that contains 17 times the gluten content of the 1960's dwarf version? Gluten exposure has proved to be devastating. Malnutrition from gluten exposure brings on an array of other disease processes. (6) Do you "NOT see" that the thrust of this article is to accustom people into accept altering their DNA in order that it fit into the "grass" world. The grain cultivators now know the impact of the mess that they created and care not what further devastation lays in wait.

 
Shannon
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
05 Jan 2018 5:47:03 PM PST
Read "Altered Genes, Twisted Truth" for scientific look at GMO's.

 
Laura
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
08 Jan 2018 6:04:09 PM PST
I'm watching the video now at https://www.c-span.org/video/?432111-2/altered-genes-twisted-truth. L-TRYPTOPHAN producing GE altered bacteria (in which gene pairs were added) were over stressed. The organism produced un-natural by product. These toxins were not identified prior to the sleep aids release to the public. The toxins injured 4 to 5 thousand people many of whom suffered death and/or permanent disabilities. GE side effects were known, yet denied by the FDA per this report. The smartest of microbiologists supported the "bean bag gene theory" which was later proven to be wrong. Humans are currently living in dangerous times.




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Same stuff, different brand. Ingredients Mung Bean Starch. Cellophane. I don't know why I thought glass. The Hokan Saifun is $2.09 for 3 noodle cakes 3.75 ounces. ingredients: mung bean flower and water. After it is cooked I snip it with scissors. Saifun noodles are known as: Mung Bean Thre...

If your concerned on wheat/gluten, see about getting a actual celiac blood test done, you have to be eating wheat for the test to be accurate. After that you will need the follow up endoscope and biopsy. http://www.cureceliacdisease.org/screening/

I play a few online games...not as much as I used to, and I no longer really do the social aspect of them. EVE Online when bored I might just get on it and mine some asteroids, or run missions while watching anime or reading a book...makes me feel productive "Multitasking" lol. I have a few phone...

Two options for online noodles that are lower carb, the cellophane noodles as suggested but I really do swear by Miracle Noodles which are No to low carb. They have and adjustment phase...they are pure fiber noodles. They can cause issues if your not used to them, or if you have bad gut bacteria....

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