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Australian Researchers Begin Work on a Vaccine for Celiac Disease

Celiac.com 10/29/2002 - Dr Robert Anderson, Research Fellow at the Nuffield Department of Medicine at the University of Oxford (now based at the Royal Melbourne Hospital in Australia), and colleagues recently announced their intent to begin work on a vaccine that could cure celiac disease. The Australian teams work will be based on Dr. Andersons earlier groundbreaking Oxford research that identified the specific set of protein sequences in gluten that cause damage to the guts of those with celiac disease (see: Nature Medicine 6, 337 - 342 - 01 Mar 2000). In addition to finding a possible cure for celiac disease the teams research could open the door for a specific diagnostic test for the disease, new treatment and prevention strategies, and even the possibility of producing grains that do not contain the harmful sequences. Dr. Andersons future research will focused on proving that a specific "toxic peptide" can be used to desensitize or induce tolerance in people with celiac disease, and any vaccine would likely be the "toxic peptide" itself or a modified form of it.

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The Australian team also announced their agreement for the commercialization of new celiac disease technology developed by the University of Oxford. BTG and Isis will develop diagnostic tests and treatments for gluten intolerance. BTG is a London-based technology transfer company which has bought the rights to the teams discovery, and Isis Innovation Ltd, is Oxford Universitys wholly-owned technology transfer company that was established in 1988 and is a world leader in university technology transfer. Under the terms of the Isis agreement, BTG will have exclusive access to the Universitys technology for use in the diagnosis, prevention and treatment of celiac disease. The technology is based on identification of the particular epitopes that cause priming of the immune system in celiac disease. BTG will underwrite all costs associated with the development and commercialization of the technology, and will share any revenue from commercialization of the technology with Isis and the University.

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Thank you i have the colonoscopy on Tuesday and am dreading the prep more than anything lol. I think what ever the outcome I will try a gluten free diet to see if it helps with the symptoms. I've read so many stories of people going gluten free and symptoms such as depression, anxiety...

A positive on any one celiac test should lead to an endoscopy/biopsies being done by a gastroenterologist. You should keep eating gluten until the endoscopy is done.

Hi LexieA, It's perfectly ok to grieve or feel down because of a diagnosis of celiac disease. Feelings are not obligated to perform on command. But, over time you can adjust to the new diet reality and even like it. Getting used to eating mostly whole foods and more natural foods is a goo...

Hertzya, Congrats to you for sticking with your service in spite of celiac disease. That seems like it would be hard to do, And thanks for your service to our country!

Thank you all