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Histology of the Terminal Ileum in Celiac Disease
Celiac.com 06/28/2004 – The results of this study indicate that the damage caused by celiac disease can be more extensive than once thought, and that it likely affects the entire small bowel, rather than just the lamina propria and crypt regions. These results also give gastroenterologists more tools for discovering the disease, as they can now find indications of it when doing a colonoscopy, which is typically done to screen for other disorders such as colon cancer. If all gastroenterologists follow these new recommendations it will speed up a celiac disease diagnosis for many people, and will also help prevent missed diagnoses.
W. Dickey and D. F. Hughes
Depts. of Gastroenterology and Histopathology Altnagelvin Hospital Londonderry Northern Ireland
Background: The histological lesion of gluten sensitivity primarily affects the proximal small bowel. The purpose of this study was to assess whether there were features of gluten-sensitive enteropathy in biopsies taken from the terminal ileum during colonoscopy/ileoscopy. Specific and sensitive abnormalities might facilitate diagnosis of coeliac disease in patients undergoing colonoscopy as their initial procedure or help select those who should proceed to upper gastrointestinal endoscopy and duodenal biopsy.
Methods: Terminal ileal biopsies, taken from 30 patients with duodenal villous atrophy consistent with coeliac disease and from 60 control patients with no evidence of coeliac or inflammatory bowel disease, were reviewed blindly and compared. Biopsies were assessed for the presence or absence of villous atrophy and crypt hyperplasia, and counts were made of intraepithelial lymphocytes (IELs).
Results: One patient only, in the coeliac group, had partial villous atrophy with crypt hyperplasia in the terminal ileum. IEL counts were significantly higher (P<0.005) in the coeliac group than among controls (mean per 100 enterocytes 26 versus 10). An ileal IEL count and 25 had a sensitivity for duodenal villous atrophy (VA) of 60% and specificity of 100%.
Conclusions: Coeliac disease may affect the entire small bowel. Increased IEL density in the terminal ileum is associated with duodenal VA and should prompt a search for coeliac disease by serology and duodenal biopsy. Conversely, a normal IEL count does not allow the exclusion of coeliac disease with confidence.
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Different Binding Motifs of the Celiac-associated HLA Molecules DQ2.5, DQ2.2, and DQ7.5
It's well documented that HLA-DQ molecules play a role in the pathogenesis of celiac disease through the presentation of gluten peptides to CD4(+) T cells.... [READ MORE]
Study Supports Gluten-free Diet for 'Potential' Celiac Disease Patients
Should everyone with symptoms of celiac disease go on a gluten-free diet? Current practice allows many patients with symptoms of celiac disease, but no gut damage, and thus no official diagnosis, to forgo a gluten-free diet.... [READ MORE]
Polymeric Binders Block Gliadin-induced Intestinal Cell Toxicity
A team of researchers recently set out to investigate the ability of a polymeric binder to reverse the toxic effects induced by gliadin in human intestinal cells and gliadin-sensitive HCD4-DQ8 mice.... [READ MORE]
Celiac Disease and Mineralization Disturbances of Permanent Teeth
Rasmusson CG, Eriksson MA.... [READ MORE]
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I foundedÂ The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.View all articles by Scott Adams
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