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Hookwormed status report


dixonpete

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Not much going on to report. My last inoculation of 25 Necator americanus hookworm larvae occurred April 11 2025, and I'm due to start incubating Aug 27 2026 and inoculate again with 25 larvae Sep 3 2025. Over the years I've seen my celiac/ulcerative colitis symptoms return six month-ish after inoculation, so I've settled on a frequency of a little less than 5 months, or in this instance, 4.79 months.

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Human hookworms (NA) don't reproduce in the body and since my immune system is constantly attacking them, I assume that attrition starts in earnest probably at the halfway point and by 5 months I might have between 10-18 left. This is strictly a guess but I think a reasonable one. I haven't noticed any GI symptoms at the 5 month mark, so that implies 10-18 functioning hookworm adults is all I need to stay healthy, but to stay that way for the duration I need to inoculate with 25 larvae. I'm obviously just spitballing here, but I'll continue to think this way until evidence to the contrary comes in. Everyone is different in terms of how many larvae they need to feel better and for how long. It all depends on the host's immune system and perhaps whether the person suffers from Inflammatory Bowel Disease. IBD sufferers tend to burn through hookworms faster than the general population.

Spidey guarding my microscope until the next incubation cycle.

spidey.png

3 Comments


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miguel54b

Posted

Thanks, I am desperate to find a cure too. 4am and I just figured out why I am not felling right (Beef jerky).

dixonpete

Posted

I was lucky (!) in that I would very quickly get sick after ingestion with something contaminated with gluten so it was easy to figure out the offender. I also had a very restricted diet and only ever introduced one new food item per day for this very reason.

One memory that sticks out was pistachios. They put flour in the bag to stop the nuts sticking together. I never would have guessed that so I didn't check the ingredient list. Gluten in an antihistamine capsule was another memorable one.

dixonpete

Posted

8 hours ago, miguel54b said:

Thanks, I am desperate to find a cure too.

I should add that hookworms aren't a cure for celiac disease. Some people, and I couldn't tell you how many, stop evincing the symptoms of celiac disease while their hookworm colonies are healthy. Others have a reduction in the severity of their reactions to gluten, but should still stay well away from it. And other people don't seem to be helped much at all.

My theory all this is because of the different root genetics of the individual's celiac disease. My cousin is also celiac, and I'm highly confident he would be put in remission with hookworms like I was, but he has no desire to try them, so I'll never know if I was right.

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