See who reacted to this (23046) - Are Celiac Disease Drug Treatments Just a Pipe Dream?

Welcome to Celiac.com!

You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.
Celiac.com Sponsor (A1):

Celiac.com Sponsor (A1-M):
Get Celiac.com Updates:

Support Our Content

eNewsletter

Donate
- All (2)
- Like (1)
- Thanks (0)
- Haha (0)
- Confused (0)
- Sad (0)
- Upvote (1)
1. sc'Que?
  September 28, 2022
Get Celiac.com Updates:

Support Celiac.com:

Join eNewsletter

Donate
About Me

Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

>VIEW ALL ARTICLES BY JEFFERSON ADAMS
Celiac.com Sponsor (A17):

Celiac.com Sponsor (A17):

Celiac.com Sponsors (A17-M):
Related Articles
Why All the Hate for Celiac Disease Drug Treatments?
Celiac.com 09/18/2015 - That old saw about death and taxes might need a bit of amending to include complaints about pharmaceutical companies working on celiac drug treatments.
One interesting facet of our coverage of the development of various drugs to treat and/or cure celiac disease has been the regular presence of comments questioning the motives,and actions of the companies involved.
It's funny, but no one complains that companies still make money selling aspirin, and that no one has cured a headache, and that there must be some conspiracy to profit off of those who suffer a headache.
There's no doubt that there's money to be made producing drugs that treat disease. But, if a company can develop and produce a safe drug to protect celiacs against contamination,...

Read Full Article...

34 comments

12,256 views
The Appeal of Vaccine Treatments for Celiac Disease
Celiac.com 12/21/2020 - Recent leaps in understanding the development of celiac disease have led efforts toward a new, non-dietary, vaccine therapy.
A lifelong gluten-free diet remains the only treatment for celiac disease, but research shows that even the most diligent gluten-free dieters are likely to be exposed to gluten on a regular basis. This is part of the appeal of safe, effective non-dietary treatments for celiac disease. And adjunctive and/or vaccine therapy is one of those approaches.
New therapies might focus on immune regulation by IL-10, as in vitro models of treated celiac patients show that external IL-10 can overwhelm the gliadin driven IFN-γ response in intestinal biopsies. But, even though people with active celiac disease show high levels of anti-infl...

Read Full Article...

4 comments

11,587 views
Once Promising Celiac Drug Larazotide Looks Doomed After Disappointing Phase 3 Trial
Celiac.com 07/18/2022 - Currently, a gluten-free diet is the only treatment for people with celiac disease. A number of companies have been attempting to create treatments that reduce or eliminate celiac disease symptoms, mostly for patients on a gluten-free diet.
Larazotide, whose clinical trial is dubbed "CedLara," is such a drug. It's designed to reduce persistent celiac disease symptoms for people on a gluten-free diet.
In an earlier phase 2 trial, Larazotide was shown to reduce celiac symptoms in patients who had been on a gluten-free diet for at least 12 months. Many were excited to see how it would do in a phase 3 trial. The answer, unless we get some better news from 9 Meters Biopharma, the company that has been developing it, is badly.
For the phase 3 t...

Read Full Article...

3 comments

12,210 views
Latiglutenase Protects the Gut and Improves Symptoms in Celiacs Who Eat Gluten
Celiac.com 09/05/2022 - According to studies, most people with celiac disease are exposed to gluten on a regular basis, even those who are trying to be diligent about avoiding gluten. For these people, eating gluten can trigger gastrointestinal symptoms and intestinal damage.
Anyone whose ever had that happen can testify to the unpleasant results, including the stomach pain, bloating, diarrhea, and other symptoms. Currently, there aren't too many options for celiacs who are exposed to small amounts of gluten, especially for those exposed on a regular basis.
A team of researchers recently set out to assess changes in the ratio of villus height to crypt depth in celiac patients exposed to 2g of gluten per day for 6 weeks, as part of a study on IMGX003 (Latiglutinase). On be...

Read Full Article...

0 comments

10,842 views
Recent Activity
1. 6 hours ago - Wheatwacked replied to JoJo0611's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  4
  
  Chances of being coeliac
  
  Welcome @JoJo0611. That is a valid question. Unfortunately the short answer is slim to none. Be proactive, when the diagnosis process is completed, start GFD. Remember also that the western diet is deficient in many nutrients that governments require fortification. Read the side of a breakfast cereal box. Anti-tTG antibodies has superseded...
2. 6 hours ago - captaincrab55 replied to AnnK73's topic in Gluten-Free Foods, Products, Shopping & Medications
  28
  
  Celiac getting dentures
  
  Can you please share your research about MMA acrylic containing gluten? I comin up blank about it containing gluten. Thanks in Advance, Tom
3. 8 hours ago - Aretaeus Cappadocia posted a topic in Gluten-Free Restaurants
  0
  
  Dedicated gluten-free Restaurants in East Bay (near San Francisco):
  
  I strongly recommend 2 dedicated gluten free (gluten-free) restaurants in my area (East Bay of San Francisco Bay Area) (2025) -- Life is Sweet Bakery and Café in Danville. I've been a few times with friends and tried multiple entrees and salads. All very good and worth having again. I've also tried a number of their bakery goods. All extremely good ...
4. 9 hours ago - Martha Mitchell replied to AnnK73's topic in Gluten-Free Foods, Products, Shopping & Medications
  28
  Celiac getting dentures
  
  I'm 67 and have been celiac for 17yrs. I had cataract surgery and they put a gluten lens in my eye. Through a lot of research, I found out about MMA acrylic...it contains gluten. It took 6 months for me to find a DR that would remove it and replace it with a gluten-free lens . I have lost some vision in that eye because of it . I also go to a prosthodontist...
  
  1
5. 10 hours ago - trents replied to JoJo0611's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
  4
  
  Chances of being coeliac
  
  If this applies geographically, in the U.K., physicians will often declare a diagnosis of celiac disease based on the TTG-IGA antibody blood test alone if the score is 10x normal or greater, which your score is. There is very little chance the endoscopy/biopsy will contradict the antibody blood test.