Celiac.com 02/01/2018 - To make a clinical diagnosis of celiac disease, doctors use serological testing for IgA antibodies to human tissue transglutaminase (anti-tTG) which indicate celiac disease autoimmunity. However, some tests are more highly sensitive for anti-tTG, while other tests are highly specific. So, is combining two tests a reliable strategy for screening for celiac disease in clinical practice?
A team of researchers recently compared the performance of three kits used to diagnose celiac disease, and evaluated the point prevalence of celiac disease autoimmunity in a South Indian urban population.
The research team included G Venugopal, J Mechenro, G Makharia, A Singh, S Pugazhendhi, R Balamurugan, and BS Ramakrishna. They are variously associated with the SRM Institutes...

Celiac.com 05/04/2021 - Immunoglobulin A tissue transglutaminase gives doctors a noninvasive way to spot celiac disease, but new research suggests that its sensitivity may be lower than estimated, making it a poor screening test, at least in asymptomatic patients. 
The reason comes down to verification bias, wherein a technique appears to have higher sensitivity and lower specificity than it actually does, because individuals who screen positive are more likely to have their disease confirmed by a follow-up small-bowel biopsy, while those who screen negative are unlikely to have a follow-up biopsy that could reveal missed celiac disease.
That matters because the disparity could lead to missed celiac diagnoses, because some of those in the negative group could actually have ...

Celiac.com 08/15/2022 - In a significant finding, a celiac disease registry at University of Alabama reveals significant issues in accurately testing Black people for celiac disease using the TTG antibody test. The new registry of celiac disease patients at the University of Alabama at Birmingham is the work gastroenterologist Dr. Amanda Cartee, MD, and fellow colleagues at UAB.
Among the most important findings, the registry reveals that Black people with biopsy confirmed celiac disease are exponentially more likely than non-Hispanic whites to show negative results on the most common diagnostic celiac disease blood test. 
For people with celiac disease, a positive TTG antibody test is the most common path to an endoscopy and biopsy to confirm or negate celiac disease.
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09/12/2022 - In most cases, celiac disease is diagnosed using anti-tTG, anti-DGP, or EMA serological tests, and then confirmed via duodenal biopsy. Xerostomia or dry mouth is a common problem for people with celiac disease. Xerostomia interferes with normal salivary gland function, causing dry mouth, which can trigger oral plaque and periodontal disease.
Looking to establish a non-invasive method for diagnosing celiac disease, a team of researchers recently set out to compare salivary and serum levels of tissue transglutaminase IgA (tTG-IgA), and to assess the severity of xerostomia symptoms in people with celiac disease. The research team included Mehran Ajdani, Nazanin Mortazavi, Sima Besharat, Saeed Mohammadi, Taghi Amiriani, Ahmad Sohrabi, Alireza Norouzi, and  Ghezeljeh Edris....