Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Support Our Content
    eNewsletter
    Donate

Intersting read on capsium, marijuna and your gut.


Ennis-TX

Recommended Posts

Ennis-TX Grand Master

Open Original Shared Link

Found this and found it interesting,  I will admit I love making edibles and it always seemed to help with my gut lol.

"Your gut is something of an Open Original Shared Link mystery.

Unlike the rest of the body, which tends to treat foreign invaders with a singular purpose—seek and destroy—the stomach cannot afford to be so indiscriminate. It exists to help fuel the body, and that means routinely welcoming foreign bodies in the form food.

“If we injected ourselves with the food that we eat, we would have a massive immune response,” said Pramod Srivastava, an immunologist at the University of Connecticut School of Medicine.

When our gut’s immune system starts acting more like that of the rest of the body, the gut gets inflamed and starts attacking its own cells. The end result is illness. Diseases like Open Original Shared Link (an autoimmune reaction to gluten) and ulcerative colitis (one of two types of Inflammatory Bowel Disease, the other being Crohns) occur when the gut’s immune system starts treating food, and our own body, like an interloper. These conditions often leaves sufferers in tremendous pain and at an increased risk of both malnutrition and colon cancer. But if researchers could figure out how to calm down that immunological response, it might be possible to create a treatment.

Srivastava’s recent study in the Open Original Shared Link suggests we may be one step closer to finding a cure. He found that anandamide, a chemical that the body makes naturally and that is very similar to chemicals found in Open Original Shared Link, helps calm down the immune system—at least in the guts of mice. If his studies hold up in humans, he says it could eventually lead to a cure for ulcerative colitis.

To understand how Srivastava came to this conclusion it helps to look at his earlier work. Srivastava found that when he exposed immune cells to hot temperatures that the cells became highly activated—in other words, the immune cells went to work. Previous studies have shown that elevated body temperatures (better known as fevers) can help immune cells work better. But what Srivastava wanted to know was why. How exactly did the cells know that it was getting hot in there?

“It was known that there were certain calcium cells that open up in the nerves when they are exposed to high temperature,” said Srivastava. “So, if the hand encounters a hot stove, those calcium cells open, calcium falls into the nerve and that nerve impulse goes to the brain, and we know that it is warm or hot.” It turns out that the same calcium channel is also how immune cells knew that their Petri dishes were getting warm.

If physically hot temperatures activate the immune cells, Srivastava wondered, would capsaicin—the chemical that makes Open Original Shared Link feel hot—do the same? The answer was yes. Immune cells exposed to chili pepper in a Petri dish behaved just like cells exposed to higher temperatures.

But our cells aren’t exposed to capsaicin directly when we bite into a spicy dish. So Srivastava fed the chemical to mice with type 1 Diabetes (which, like IBD, stems from autoimmune inflammation) to mimic our actual exposure. Since the Petri dish experiments showed that heat and capsaicin tended to make immune cells more active, the mice fed capsaicin should have developed more diabetes than the control group. But the opposite happened. Srivastava found that capsaicin didn’t ramp up the immune cells in their guts—it chilled them out. The mice fed capsaicin actually stopped being diabetic.

It turns out something else happens when a mouse chows down on capsaicin. A special kind of immune cell, CX3CR1, also gets activated. And that immune cell tends to suppress immune responses in the gut. Since the body can’t really depend on a steady diet of chili peppers to keep us healthy, Srivastava went looking to see what else binds to the same calcium channel as capsaicin. He discovered that anandamide does.

Anandamide was discovered in the 1980s when researchers were trying to make sense of why our body, especially the brain, has cannabinoid receptors. Cannabinoids, found in marijuana, are part of a class of chemicals that can alter neurotransmission in the brain. Nature didn't develop those sensors just so humans could get stoned: anandamide is similar to the cannabinoids found in marijuana, but our body actually produces it.

“The person who discovered anandamide had an interest in Indian languages,” said Srivastava. “And in India, the word ‘ananda’ means bliss.”

Nobody knows whether anandamide actually induces a sense of bliss, but mice fed anandamide experienced the same healing effects—stretching from the esophagus down through the stomach—as mice fed capsaicin. Srivastava also discovered that when he gave mice capsaicin, it seemed to stimulate their bodies' production of anandamide. In both cases, it was ultimately the anandamide that was healing the gut, which suggests that other cannabinoids like marijuana might have a similar effect.

As with all studies, there are some limitations. Srivastava’s work was done in mice, not people. But it does fall in line with anecdotes from IBD sufferers who have found that marijuana relieves some of their symptoms, and other studies that have found that people who eat chili peppers live longer.

Because anandamide is a cannabinoid, it’s pretty heavily regulated—you can’t just give it to humans. As a result, Srivastava hopes to work with public health authorities in Colorado—the land of medical (and recreational) marijuana—to see if legalization has led to any improvement in colitis patients who consume edibles. If it has, that could help Srivastava make the case for a study that repeats his experiment in human patients.

In the meantime? Well, if you live in Colorado and want to try something new for your IBD, you're sure in luck. But most patients should probably hold off on trying to mimic the study results at home: Open Original Shared Link, likely because they increase stomach acid and often contain nightshade plants. So guzzling hot sauce might not be a safe way to boost your body's anandamide production."


Celiac.com Sponsor (A8):
Celiac.com Sponsor (A8):



Celiac.com Sponsor (A8-M):



Ennis-TX Grand Master

OH odd info here but the best way I found found to use it is a slow low temp extraction into coconut oil, and using this oil in cooking. Use a mortar and pestal to grind your greens into a fine powder, and heat slowly in a pan with virgin coconut oil just very low temp for a while you will see the oils from the greens mix with the coconut oil. You can then use this oil blend in baking edibles, or in whatever you wish. I make it very weak myself with just small bag in a entire 16oz container of coconut oil. I do it for the medical benefits nothing else. I like using it in paleo breads, or drizzle a bit over salads,  

CBD oil also has some benefits I have noticed in smaller amounts and CBD is legal in most states the gold one seems to be the best.

Archived

This topic is now archived and is closed to further replies.

  • Get Celiac.com Updates:
    Support Celiac.com:
    Donate

  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Recent Activity

    1. - chrish42 replied to chrish42's topic in Doctors
      2

      Doctors and Celiac.com

    2. - Scott Adams replied to shirlane's topic in Gluten-Free Foods, Products, Shopping & Medications
      1

      Is AG1 safe for Celiacs??

    3. - Scott Adams replied to chrish42's topic in Doctors
      2

      Doctors and Celiac.com

    4. - nataliallano replied to MagsM's topic in Related Issues & Disorders
      28

      Inflammation and Menier’s disease link?

    5. - Wheatwacked replied to Betsy Crum's topic in Related Issues & Disorders
      5

      Chest pain from celiac


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      130,257
    • Most Online (within 30 mins)
      7,748

    Y2Kimberly
    Newest Member
    Y2Kimberly
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      121.3k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Upcoming Events

  • Posts

    • chrish42
      All I can say is this site is great!
    • Scott Adams
      From their website I see "organic barley leaf powder" as an ingredient. Keep in mind that the gluten is in the kernel, and not in the leaves. https://drinkag1.com/about-ag1/ingredients/ctr
    • Scott Adams
      Before the rise of social media we were well known by a lot of doctors and were recommended by many, especially our Safe & Forbidden Lists, but as doctors get younger and younger this is probably not happening as much as before. 
    • nataliallano
      Thanks Scott I will definitely check my vitamins and minerals to see what I am missing so then I can supplement. I was very concern about my Meniers syntoms and i tryed to find some alive. Now im just realizing that my celiac is provably the root cause of my Meniers none of the 12 doctors I saw told me anything about this.  This web site is so helpful, thanks to people like you we can get answers. 
    • Wheatwacked
      Vitamin D deficiency can contribute to rib pain. Chest pain stemming from the ribs ccould be costochondritis, which involves inflammation of the cartilage connecting the ribs to the breastbone. This pain can range from mild to severe, potentially mimicking heart attack symptoms, and is often worsened by breathing or movement. Other potential causes include muscle strain, rib fractures, or even referred pain from other conditions.  It will also help to chose vegetables low in omega 6.
×
×
  • Create New...