Understanding ANA results

[rowanie]

Hi there,

Thanks for taking the time to read this. 

I am so very confused, so thought I’d ask for help to see if anyone can understand my ANA results. I am currently under investigation for celiac and for ulcerative colitis. 

I had some bloods done last month and only through deciding to do a private referral (I am in the UK) have I found out there there are some abnormalities in my antinuclear antibodies. I asked my doctors for a print out of all my bloods. 

I have lower white blood cells, my ESR is very slightly raised. These are my ANA results:

ENA ANTIBODIES - (SJM) 

• Ro antibody level - negative

• La antibody level - negative

• RNP antibody level - weak positive

• Sm antibody level - negative

• Jo-1 antibody level - negative

• Scl 70 antibody level - negative

DNA binding autoantibodies (SJM) - negative

• Complement - third component - C3 - 1.39g/l (range 0.55-1.20)

HEP2 ANA - (SJM) - Cytoplasmic

Does anyone understand what this means? Do I ignore it? Why does it not say ANA negative or positive, but says cytoplasmic instead? Why is there no titre? 

I am no doctor so I have no idea, but I’d really like your opinion. Something has obviously been picked my from the lovely doctor I saw privately. I also have Raynauds  

Thanks so much for your help. 

[chocolatesunrise]

8 hours ago, rowanie said:

Hi there,

Thanks for taking the time to read this. 

I am so very confused, so thought I’d ask for help to see if anyone can understand my ANA results. I am currently under investigation for celiac and for ulcerative colitis. 

I had some bloods done last month and only through deciding to do a private referral (I am in the UK) have I found out there there are some abnormalities in my antinuclear antibodies. I asked my doctors for a print out of all my bloods. 

I have lower white blood cells, my ESR is very slightly raised. These are my ANA results:

ENA ANTIBODIES - (SJM) 

• Ro antibody level - negative

• La antibody level - negative

• RNP antibody level - weak positive

• Sm antibody level - negative

• Jo-1 antibody level - negative

• Scl 70 antibody level - negative

DNA binding autoantibodies (SJM) - negative

• Complement - third component - C3 - 1.39g/l (range 0.55-1.20)

HEP2 ANA - (SJM) - Cytoplasmic

Does anyone understand what this means? Do I ignore it? Why does it not say ANA negative or positive, but says cytoplasmic instead? Why is there no titre? 

I am no doctor so I have no idea, but I’d really like your opinion. Something has obviously been picked my from the lovely doctor I saw privately. I also have Raynauds  

Thanks so much for your help. 

Hi!

These types of tests can be really confusing to interpret on your own. Will you be seeing your doctor soon to go over these?  I believe the “cytoplasmic” result just refers to where in the cell there was evidence of binding to antigens. In other words, it has to do with which part of the cell there are autoantibodies found in. That ultimately can point towards certain autoimmune disorders, but doesn’t definitively diagnose you with any particular disease. Have you had a celiac panel performed yet?  Just curious why your doctor ordered this panel as a workup for celiac?  I guess I don’t really have an answer for you but I know how frustrating it is to have to wait around for answers!  I hope you get some info from your doctor soon. ?