positive DGP IGG and HLADQ2 + classic symptoms... does a biopsy result really matter?

[nickibeaks]

This has been a lifetime pursuit to try and figure out my stomachs issues. This is my first time having the DGP tested, and had the imaware screen. It came up positive but negative ttg IgA. Based on my reading, and yes I’m aware that the gold standard is DGP is only for immunodeficiency patients, it seems like DGP is very accurate but is less often used because of its low predictive value. I had gone  2 months gluten free and was back to eating it for  2 weeks when I took the test

 

at this point I am relieved to know that it’s very likely celiac, but also discouraged because my lab work isn’t cut and dry, and I’m nervous that my biopsy will be negative next week. To me, even if it is all roads lead to celiac, or severe gluten sensitivity. At the end of the day I just don’t get why it matters so much to be able to see damage. I don’t want to go another 6 months eating gluten in order to try another biopsy

[Fenrir]

Unfortunately, it sounds like your situation is still questionable. 

This may be due to the fact that you were sporadically eating gluten around testing times. I think at this point if you don't want to start eating gluten to get accurate testing or have a biopsy then just go gluten-free , completely. If you aren't feeling better after a month then you may want to keep looking for the reason. 

[nickibeaks]

Holy cow, I just got the quest lab results that were done a few weeks after the first one, so more gluten exposure. My TTG IgA was high at that point, as well as my total IgA.

biospy is Wednesday... maybe it’ll come back conclusive for celiac and I will finally have an answer to a lifetime of illness