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High Deamidated Gliadin Ab, IgG and positive DQ2

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I am having my granddaughter, age 17, tested for celiac because of stomach issues. In addition to the results below, she has very low unsaturated B12 binding capacity and liver functions came back high (had been low 6 months prior). She gained a tremendous amount of weight and her body changed dramatically (in addition to the weight gain). She has kept gluten in her diet until we have more info. Your input on the results below will be greatly appreciated.

DQ2    Positive

DQ8    Negative

Immunoglobulin A                             100                Range: 50-300

Anti TTG IgA Antibodies                    1.6                 Range:<10.1

Deamidated Gliadin Ab, IGA              10                  Range: 0-19

Deamidated Gliadin Ab, IgG               76                 Range: 0-19

Endomysial Antibody IgA                   Negative  

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Welcome to the forum!

Can I assume that your granddaughter was eating gluten daily in the weeks leading up to her blood draw for the celiac disease tests? If not, that can reduce her levels, and cause false-negative results. 

Also, given the high positive on the IgG anti-gliadin antibodies and positive genetic marker for CD, did her doctor recommend that she get a biopsy to confirm celiac disease? This would be the normal next step with results that are mixed like hers seem to be. The IgG anti-gliadin antibodies can be present in 21% of patients with other conditions, so this particular marker has a higher rate of false-positive results (it's less specific than the other tests which were negative--see below).

Last, if your doctor or granddaughter decide not to go the biopsy route, the next best step would be to try a 100% gluten-free diet for several months to see in her symptoms improve. About 12% of people have non-celiac gluten sensitivity, and there are currently no tests available for this, but they are working to develop them. Elevated antibodies can be an indicator, along with positive genetic markers. 

From the article below:

Quote

Both IgA and IgG anti-gliadin antibodies (AGA) are detected in sera of patients with gluten sensitive enteropathy (celiac disease). IgG anti-gliadin antibodies are more sensitive but are less specific markers for disease compared with IgA class antibodies...the IgG anti-gliadin antibodies are 91% specific and have an 87% sensitivity. This means that they will show positive results more readily but there is not as strong a correlation with celiac disease. It is less specific. Patients with other conditions but not afflicted with celiac disease will occasionally show positive results. IgG anti-gliadin antibodies are detectable in approximately 21% of patients with other gastrointestinal disorders. This test might yield false positive results but is less likely to yield false negative results.

 

Scott Adams

Celiac.com - Celiac Disease Board Moderator

Founder Celiac.com

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