Negative IGA and IGG

[Trinakd]

I got a negative on my tissue transglutaminase IGA and IGG.

0.4U/mL for IGA

<0.6U/mL for IGG

Range is <7.0 is negative, Equivocal is 7-10 and positive is >10.
 

Is it just me or are the numbers really low? What does that mean? I was eating gluten but not as much as you are suppose to as I didn’t know beforehand. Should I conclude I don’t have Celiac? 😄😄😄😄

 

[trents]

What was your total IGA score and what is the reference range for that laboratory? If total IGA is low then it skews the individual tests downward.

If you were practicing a low gluten diet for some weeks before testing that could be the reason for the low scores. You could also be looking at NCGS (Non Celiac Gluten Sensitivity).

What made you look into testing for celiac disease? What are your symptoms?

[Trinakd]

Reference range is <7.0 is negative, 7-10 is equivocal and >10 is positive, I do not see a total amount.
 

I was tested for several different illnesses. I have constipation, diarrhea, stomach pain, brain fog, bloating, and gas. Lots of acid reflux but I assumed that’s it’s own issue.

[trents]

NCGS produces many of the same symptoms as celiac disease but does not cause damage to the small bowel villi, and hence does not produce positives on the antibody tests or with the endoscopy/biopsy of the small bowel. There is also the occasional situation where someone who really does have celiac disease tests negative for antibodies. The endoscopy/biopsy of the small bowel lining is the gold standard.

As I see it you have three options:

1. Start eating significant amounts of gluten (the equivalent of two slices of wheat bread daily for 6-8 weeks before testing) and get retested for antibodies.

2. Start eating regular amounts of gluten for at least two weeks and get an endoscopy/biopsy.

3. Assume you have either celiac disease or NCGS and commit to total elimination of gluten from your diet and see if your symptoms improve within a period of several weeks.