Positive Gliadin Blood Test-

[Danadarlene]

This is a two part questions. 

1) My daughter tested positive for celiac (numbers below) but her scope came back negative.  They did visually see some ridges and noted "duodenal bulb atrophic mucosa" on one of her images.  Can you see issues during the scope and it not be related to celiac? I couldn't see a way to attach a photo or I would.   She was still eating gluten, but she is not a huge fan of gluten food, so she was not as diligent at eating it everyday as she should have been.

Tissue Transglutaminase IGA 5
> or = 4 Antibody Detected

Gliadin (Deamindated) AB (IGG)-29
> or = 20 Antibody Detected

2) After my daughter tested positive, I had my yearly appointment and had a full celiac panel done.    I also don't eat a lot of gluten everyday, so curious if my Gliadin IGA would have been higher if I had been eating more gluten.  After the positive blood test, I have been consistently eating two slices of gluten everyday and have my scope on January 14th.  My GI acted like my scope will for sure come back negative because the below tests typically give false positives.  Has anyone had a positive scope with only the Gliadin test positive?

Gliadin (Deamindated) (IGA)-14.4
> or = 14.9 Antibody Detected

Gliadin (Deamindated)  (IGG)-33.4 (H)
> or = 14.9 Antibody Detected

Tissue Transglutaminase IGA and IGG both negative

Thanks!

[Scott Adams]

If I am reading your results correctly, your daughter's tTG, which is the most specific blood test for celiac disease, was 5, and anything above 4 is positive. Her Gliadin (Deamindated) AB (IGG) was 29, and anything above 20 is positive. So it looks like she has two positive blood test, AND a positive biopsy, and this means she clearly has celiac disease. 

Additionally, it sounds like she was not eating the required 2 slices of wheat bread per day for at least 6-8 weeks before her test, which could make her scores lower than they could have been.

In your case I am not sure why your doctor would say that the blood tests you were given "typically give false positives," which isn't true. Your Gliadin (Deamindated)  (IGG) is positive, and your Gliadin (Deamindated) (IGA) is elevated, and nearly positive. Given the fact that your daughter likely has celiac disease, your chances of having it are ~44%, so it looks like you likely also have celiac disease. 

This article explains the blood test results in more detail:

 

[Danadarlene]

1 hour ago, Scott Adams said:

If I am reading your results correctly, your daughter's tTG, which is the most specific blood test for celiac disease, was 5, and anything above 4 is positive. Her Gliadin (Deamindated) AB (IGG) was 29, and anything above 20 is positive. So it looks like she has two positive blood test, AND a positive biopsy, and this means she clearly has celiac disease. 

Additionally, it sounds like she was not eating the required 2 slices of wheat bread per day for at least 6-8 weeks before her test, which could make her scores lower than they could have been.

In your case I am not sure why your doctor would say that the blood tests you were given "typically give false positives," which isn't true. Your Gliadin (Deamindated)  (IGG) is positive, and your Gliadin (Deamindated) (IGA) is elevated, and nearly positive. Given the fact that your daughter likely has celiac disease, your chances of having it are ~44%, so it looks like you likely also have celiac disease. 

This article explains the blood test results in more detail:

 

Thanks Scott for the reply.  My older daughter's scope actually came back negative even though they noted "duodenal bulb atrophic mucosa" on one of her images which you can see here.  The doctor even talked for a while to me about the noted image, but then the results came back negative. Of course the nurse is the one who called with the results.  Can one normally see this type of ridges during a scope and not have celiac? 

I agree about my results. 

I had my youngest daughter retested last week.   She has Turners Syndrome, so she is tested every year and did have a scope done when she was 4 which came back negative.  However, because of my older daughters test results and mine own, I started looking into all of my youngest her past test results and she appears to be IGA deficient and they have only been testing her TtG IGA.   I requested a full celiac panel and her results came back today showing she is IGA deficient but thankfully they did all four test and she came back negative to all four.

 

 

[Danadarlene]

1 hour ago, Scott Adams said:

If I am reading your results correctly, your daughter's tTG, which is the most specific blood test for celiac disease, was 5, and anything above 4 is positive. Her Gliadin (Deamindated) AB (IGG) was 29, and anything above 20 is positive. So it looks like she has two positive blood test, AND a positive biopsy, and this means she clearly has celiac disease. 

Additionally, it sounds like she was not eating the required 2 slices of wheat bread per day for at least 6-8 weeks before her test, which could make her scores lower than they could have been.

In your case I am not sure why your doctor would say that the blood tests you were given "typically give false positives," which isn't true. Your Gliadin (Deamindated)  (IGG) is positive, and your Gliadin (Deamindated) (IGA) is elevated, and nearly positive. Given the fact that your daughter likely has celiac disease, your chances of having it are ~44%, so it looks like you likely also have celiac disease. 

This article explains the blood test results in more detail:

 

I tried to post the scope image above, but it looks like it didn't Post.  I am going to try it again.

 

https://photos.google.com/share/AF1QipOXFSJW-oyQHKX6F2YrBQsfwMpUXWDYfnLQH5qlhbvE1UT2f2BgiPttjO_L4gAAEw?key=cl9uVDVtV2d5cFdfdVNMdnRsSEpzNXRicDZmb05n

[RMJ]

I would ask to see the actual pathologist’s report of the biopsies rather than rely on what a nurse said on a phone call.

[frieze]

4 hours ago, RMJ said:

I would ask to see the actual pathologist’s report of the biopsies rather than rely on what a nurse said on a phone call.

Get a copy, keep copies of all records 

[Scott Adams]

If your daughter is IGA deficient, yet still had a positive test using Tissue Transglutaminase IGA, then it's likely her score, if she were not IGA deficient, would have been much higher. I guess I'm not buying that she is "borderline," and for sure her results are not negative.

It only takes one positive blood test to indicate celiac disease, and the tTG test is considered the most accurate blood test for celiac disease.

Given the fact that she also has some "duodenal bulb atrophic mucosa," and another autoimmune disease, it would make sense for you to consider a gluten-free diet for her. I think the same goes for you as well, given your positive blood test result. At best I believe you both lie in the non-celiac gluten sensitivity zone, which includes around 10x more people than does celiac disease, yet there isn't a definitive test for it. The treatment is the same, a gluten-free diet.