Negative tTG-IgA, DGP-IgG, Gliadin IgA&IgG back in October 2021 - worth pursuing further?

[Ippodrom234]

Hi! I've been having various symptoms, such as gastritis, colon inflammation, anxiety, mood swings, etc for a couple years.

In October 2021 a did a celiac panel including:

Total IgA - normal

tTG-IgA, DGP-IgG, Gliadin IgA&IgG - all negative and very low.

Does it basically rule out celiac disease with 98-99% certainty? I'm not talking about gluten sensitivity now. I can't say my symptoms feel worse after having gluten, but they just persist.

I though about DGP-IgA, which is positive for some people despite other tests being negative, but I had the "old" test Gliadin IgA&IgG - isn't it basically the same?

Thanks!

[Ippodrom234]

Also, does doing the genetic test make sense?

[Scott Adams]

Welcome to the forum!

There are two medically recognized conditions in those who can't tolerate gluten: 1) Celiac disease, which around 1% of people have, and 2) Non-celiac gluten sensitivity, which around 10% of people have.

There is currently no test for the latter condition, NCGS, but if you have either a gluten-free diet is the only way to avoid symptoms and related issues.

Given that you tested negative but do have possible symptoms that may be related to gluten it might make sense for you to go gluten-free for a few months to see if you find relief.

You can get a genetic test if you like, but it would only reveal whether or not you carry the genetic makeup for celiac disease, and not necessarily NCGS.