TTG-IGG

[GUY1]

It would be yes but I don’t want to go back on gluten.At least for the time being.I guess it means that something was bothering me and it has been removed.Also from what I understand igg ttg is related mostly to  gluten than other foods

[trents]

10 minutes ago, GUY1 said:

It would be yes but I don’t want to go back on gluten.At least for the time being.I guess it means that something was bothering me and it has been removed.Also from what I understand igg ttg is related mostly to  gluten than other foods

That would be my guess. But since the AIP is a shotgun approach you can't be sure.

[trents]

This is probably a repeat post but nonetheless: 

tTG-IgG (tissue transglutaminase IgG) Blood Test for Celiac Disease

This test measures the levels of antibodies to tissue transglutaminase, but it specifically measures IgG antibodies rather than IgA antibodies which are produced in people who eat gluten and have celiac disease. It is not as sensitive or specific as the tTG-IgA test, but it may be useful in cases where a person has an IgA deficiency, which can occur in approximately 2-3% of people with celiac disease. In these cases, the tTG-IgG test may be positive while the tTG-IgA test is negative. However, the tTG-IgG test is not recommended as a first-line screening test for celiac disease.

The sensitivity of the tTG-IgG blood test is generally high, ranging from 85% to 98%. This means that the test can accurately detect celiac disease in a significant percentage of people who have the condition.

The specificity of the tTG-IgG blood test is also high, typically around 90% to 98%. This indicates that the test can effectively rule out celiac disease in individuals who do not have the condition.

From: 

 

[GUY1]

I have read this before.not sure though that the last 2 paragraphs are referred to individuals with total iga deficiency or not:

 

“The sensitivity of the tTG-IgG blood test is generally high, ranging from 85% to 98%. This means that the test can accurately detect celiac disease in a significant percentage of people who have the condition.

The specificity of the tTG-IgG blood test is also high, typically around 90% to 98%. This indicates that the test can effectively rule out celiac disease in individuals who do not have the condition.”

 

 

what do you think Trent’s?

[trents]

Whether or not someone is IGA deficient should have no impact on the IGG test. It's simply saying that although the tTG-IGA is the better test under normal circumstances (people with normal total IGA levels) for IGA deficient people the tTG-IGG is better.

[GUY1]

👍that’s what o thought.

So according to this article 85%-98% of people with positive ttg igg have celiac.I find that to be a pretty high percentage to be ignored if one has a positive test like that.Yet the doctors I have been to claim that probability is low or non existent for celiac with just ttg igg positive.

 

don’t know what to think anymore.

 

tahnks for the help again!

[trents]

Now that I read it again and think about it, it all depends on what is meant by ("people who don't have this condition") Is that referring to celiac disease or low total IGA? And note the words "This indicates that the test can effectively rule out celiac disease in individuals who do not have the condition.”

So, I'm guessing "this condition" refers to celiac disease, i.e., a negative test result for the ttg-igg can be trusted.

[knitty kitty]

12 hours ago, GUY1 said:

Hello All,

just an update....and a question.

If you scroll up to the original post my initial question was about a TTG IGG positive result with everything else within the normal range.

Update: After 2 1/2 months on a strict gluten free diet(actually went on the AIP diet) I re-tested for the TTG IGG and it came back within normal levels.3.8 u/ml.(ranges:0-5=negative, 6-9 weak positive, >9 positive).

Original test was 9 u/ml.

 

Question: I know that no one can give a definitive answer but does the reduction of antibodies (even if it is ttg igg) mean anything?also if there is a GI that reads this please chime in!:)

Reminding you that my genetic testing came back only one half positive.But also positive for DQ 7.5!

 

 

Thanks again All for your immense help!

 

I've found some interesting studies that might help you....

High Frequency of Haplotype HLA-DQ7 in Celiac Disease Patients from South Italy: Retrospective Evaluation of 5,535 Subjects at Risk of Celiac Disease

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580462/

And...

Immunoglobulin G (IgG) Anti-Tissue Transglutaminase Antibodies Used as Markers for IgA-Deficient Celiac Disease Patients

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549312/

And...

Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7878429/

[trents]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC549312/

So, kk, is this saying that the tTG-IGG is less accurate as a predictor of celiac disease in IGA sufficient patients than it is in IGA deficient patients? This is our question since the OP is not IGA deficient, had negative tTG-IGA but positive tTG-IGG.

Edited October 2, 2023 by trents

[GUY1]

Hello,

 

I have read these articles.that is why I mentioned the DQ 7,because I had seen this research in southern Italy.

As far as ttg igg goes the sensitivity is to know if you have the disease and specificity to rule it out.

 

it all is a bit perplexing but again I think gluten-free diet is the way to go when in doubt.

I ve found only very few to have confirmed celiac disease only with the ttg igg positive and no iga deficiency.

again if there is anyone out there please chime in

[knitty kitty]

@GUY1,

Have you taken immunosuppressive drugs?  Steroids?  PPI's?

[GUY1]

Sorry just saw this reply for some reason!

No haven’t taken these medications.I am assuming you re asking because they can alter blood tests,correct?

[knitty kitty]

Yes, immunosuppressive drugs can skew blood tests, as can conditions like diabetes and anemia.