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Understanding Genetic Testing: half DQ2

NikkiRose96
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NikkiRose96 Newbie
NikkiRose96
Posted

I’m trying to read my genetic report to better understand. It looks like my report came back with half a gene but my doctor stated I was negative for celiac? Has anyone had experience with a report similar to this? Is it actually negative? Unfortunately I have already been living a gluten free lifestyle so the other testing isn’t possible unless I reintroduced gluten so trying to determine the likelihood genetically first. 
 

My report came back saying: 

The patient is positive for

DQA1*05, one half of the DQ2 Heterodimer.

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knitty kitty Grand Master
knitty kitty
Posted

Welcome to the forum, @NikkiRose96!

While only having one allele for Celiac may put you in a lower risk group for developing celiac disease, it also may put you at higher risk for ulcerative colitis.

Not diagnosing.  

 

HLA-DQA1*05 Associates with Extensive Ulcerative Colitis at Diagnosis: An Observational Study in Children

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8701736/

Scott Adams Grand Master
Scott Adams
Posted

The number of genes associated with celiac disease is more than two, but there are two main genes that are commonly tested for celiac disease susceptibility. These genes are HLA-DQ2 and HLA-DQ8.

  • HLA-DQ2: The majority of individuals with celiac disease (about 90-95%) carry the HLA-DQ2 gene.
  • HLA-DQ8: Around 5-10% of individuals with celiac disease have the HLA-DQ8 gene.
  • Other Genes: While HLA-DQ2 and HLA-DQ8 are the primary genes associated with celiac disease, having these genes doesn't guarantee that someone will develop celiac disease. Additionally, a small percentage of individuals with celiac disease don't have either of these genes. This suggests that other genetic factors may also play a role, though they are less common.

This article has more information about the genes associated with celiac disease:

 

 

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