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Do we have any data on factors that decide which person that carries celiac genes is at higher risk of developing celiac disease? Specifically I'm thinking of diet related factors. Nutrition, vitamins, microbiome, etc.?

heyitsme
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heyitsme Apprentice
heyitsme
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Scott Adams Grand Master
Scott Adams
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The number of genes associated with celiac disease is more than two, but there are two main genes that are commonly tested for celiac disease susceptibility. These genes are HLA-DQ2 and HLA-DQ8.

  • HLA-DQ2: The majority of individuals with celiac disease (about 90-95%) carry the HLA-DQ2 gene.
  • HLA-DQ8: Around 5-10% of individuals with celiac disease have the HLA-DQ8 gene.
  • Other Genes: While HLA-DQ2 and HLA-DQ8 are the primary genes associated with celiac disease, having these genes doesn't guarantee that someone will develop celiac disease. Additionally, a small percentage of individuals with celiac disease don't have either of these genes. This suggests that other genetic factors may also play a role, though they are less common.

This article has more information about the genes associated with celiac disease:

 

 

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