T-tg IGA and Gliadin Antibodies Iga deficiency

[Izzysmom]

Hi everyone. My daughter is 9 and has been suffering with g.i. Issues for the past few years. Her pediatrician suspected celiac (I have it as well). We just got her labs back and I’m a bit lost and confused with them. Any advice would be appreciated 

Gliadin Antibodies Iga  value <0.72

t-TG IgA Value <1.02

 

[trents]

Welcome to the forum, @Izzysmom!

The numbers you posted aren't helpful unless you also include the lab's reference ranges for negative vs. positive. There are no industry standard ranges for celiac antibody tests in place yet so each lab uses their own. Can you post back with additional info? You will likely need to do it in a new post since the time window for editing a post is very short.

[Izzysmom]

They supplied the following ranges 

t-TG IgA Normal range: 0.00 - 4.99 FLU hers = <1.02

Gliadin Antibodies Iga Normal range: 0.00 - 4.99 FLU hers = <0.72

[Izzysmom]

Hi everyone. My daughter is 9 and has been suffering with g.i. Issues for the past few years. Her pediatrician suspected celiac (I have it as well). We just got her labs back and I’m a bit lost and confused with them. Any advice would be appreciated 
 

They supplied the following ranges 

t-TG IgA Normal range: 0.00 - 4.99 FLU          hers = <1.02

Gliadin Antibodies Iga Normal range: 0.00 - 4.99 FLU             hers = <0.72

[trents]

22 minutes ago, Izzysmom said:

They supplied the following ranges 

t-TG IgA Normal range: 0.00 - 4.99 FLU hers = <1.02

Gliadin Antibodies Iga Normal range: 0.00 - 4.99 FLU hers = <0.72

Testing terminology can be challenging but it looks like they did the TTG-IGA and DGP-IGA. They should have also done a "total IGA" test because if total IGA is low then it can cause false negatives in the individual IGA tests. Also, with children, because their immune systems are immature, they should also have run a TTG-IGG test. I would go back to the physician and request these additional tests to be run:

Total IGA

DGP-IGG

TTG-IGG

Here is an overview of celiac disease blood antibody testing: 

 

Also, if she was consciously or subconsciously limiting her intake of wheat products and therefore practicing a low gluten diet, then that would skew the numbers down toward the negative range. People need to be eating generous amounts of gluten for weeks before being tested.

Edited June 16, 2024 by trents

[Izzysmom]

1 minute ago, trents said:

Testing terminology can be challenging but it looks like they did the TTG-IGA and DGP-IGA. They should have also done a "total IGA" test because if total IGA is low then it can cause false negatives in the individual IGA tests. Also, with children, because their immune systems are immature, they should also have run a TTG-IGG test. I would go back to the physician and request these additional tests to be run:

Total IGA

DGP-IGG

TTG-IGG

Here is an overview of celiac disease blood antibody testing: 

 

Also, if she was consciously or subconsciously limiting her intake of wheat products and therefore practicing a low gluten diet, then that would skew the numbers down toward the negative range. People need to be eating generous amounts of gluten for weeks before being tested.

Thank you. I will get those requested on Monday. 
she eats her gluten and mine lol Which is why I was so surprised by the low numbers. we pay close attention to what she eats and there hasn’t been any limiting with her. 

[knitty kitty]

Anemia, diabetes and Thiamine deficiency can cause false negatives.  

Has your daughter been checked for these?

And some of us rare ones are seronegative Celiac.  

[Izzysmom]

2 minutes ago, knitty kitty said:

Anemia, diabetes and Thiamine deficiency can cause false negatives.  

Has your daughter been checked for these?

And some of us rare ones are seronegative Celiac.  

She has been, I checked both times she went to the ER and had labs. Those are all within normal range. Hemoglobin/hemacrit normal, glucose/A1c normal, but can’t find anything on testing her B1

[Izzysmom]

4 hours ago, Izzysmom said:

Thank you. I will get those requested on Monday. 
she eats her gluten and mine lol Which is why I was so surprised by the low numbers. we pay close attention to what she eats and there hasn’t been any limiting with her. 

More results just posted:

t-TG IgG Range  0.00 - 4.99 FLU     Hers <0.82

Gliadin Antibodies Igg Range 0.00 - 4.99 FLU   Hers <0.56

 

4 hours ago, trents said:

Testing terminology can be challenging but it looks like they did the TTG-IGA and DGP-IGA. They should have also done a "total IGA" test because if total IGA is low then it can cause false negatives in the individual IGA tests. Also, with children, because their immune systems are immature, they should also have run a TTG-IGG test. I would go back to the physician and request these additional tests to be run:

Total IGA

DGP-IGG

TTG-IGG

Here is an overview of celiac disease blood antibody testing: 

 

Also, if she was consciously or subconsciously limiting her intake of wheat products and therefore practicing a low gluten diet, then that would skew the numbers down toward the negative range. People need to be eating generous amounts of gluten for weeks before being tested.

 

[trents]

So it looks like total IGA still needs to be run.