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I Can't Understand These Results! Please Help!


sharps45

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sharps45 Apprentice

I went into my GP, and told him I was having some problems with oats (severe) and white breads (just gas), but no problem with pasta, pizza. My father and sister both had celiac (both also had diabetes and have passed away). Dr sent me for blood scan. Results according to him were 'borderline positive' meaning he said I had celiac. But then he told me that I could eat anything but those specific foods that caused me trouble. So now I'm not trusting his diagnosis. This is a small rural area, and a gastroenterologist is 100 miles away. So can you help me to interpret these? I'm not being lazy, I've spent a couple of hours going through the posts here and not finding the answers I need (or not understanding those I find).

The tests show a bunch of stuff under COMP. METABOLIC, but I don't think any of them are of a concern for this.

The following are things I don't understand

ALBUMIN mine= 4.0 Reference= 3.5 - 5.0

GLOBULIN mine= 3.3 Reference= 2.5 - 4.7

AST (SGOT) mine= 30 Reference= 5-45

ALT (SGPT) mine= 71 Reference= 5-65 flagged as H

ALK PHOS mine= 91 Reference= 50-136

IGA mine= 150 Reference= 81-463

TRANSGLUTAMINAS flagged A

tTG Ab, IgA mine= *6 Reference NEGATIVE <5 EQUIVOCAL 5-8 POSITIVE >8

TRANSGLUTAM IGG shows no result

tTG Ab, IgG mine= 4 Reference= NEGATIVE <7 EQUIVOCAL 7-10 POSITIVE >10

I'm assuming the 'flagged H' means high, but 'flagged A' ?? And what does the * by the 6 mean?

If anyone could help I'd really appreciate it, as my confidence in my local doc is not high at this moment. Thanks so much


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nora-n Rookie

Hi

As I read it, they ran both the tissue transglutaminase IgA test and the tisue transglutaminase IgG test.

The Ttg IgA test was weakly positive at 6 as I read it.

But, had you been low-gluten for a while? I had. Then the numbers are often low.

The Ttg-tests ave very specific for celiac but some other things may cause a false positive but that is rare. You probably already looked it up on the internet.

I am in Europe, and a person like you would be sent to a biopsy of the duodenum or small intestine.

This is both because one gets money from the government with a positive diagnosis, and to make follow-up more accurate.

Of course you must avoid all gluten, not just the things you react to. But this is much easier if you have a proper diagnosis with endoscopy. Compliance might not be that good without a proper diagnosis.....

Family and friends might respect your dietary needs much more if you have a proper diagnosis.

I have no proper diagnosis and that makes it much harder to forbid them to spread gluten crumbs all over the kitchen etc. I wish I had a diagnosis.

nora

sharps45 Apprentice

This was a right off the street test, and I'd had spaghetti with garlic bread two nights before.

Jestgar Rising Star

You need to have been eating gluten for several months beforehand. Think about your diet, was it high in bread products, or had you already been avoiding them?

sharps45 Apprentice

It was high in gluten, except for oats, which I can't tolerate at all. Muffins or bread with dinner, whole grain cereals and Malt O Meal for breakfast, lots of pasta (love tortellini!). Since getting the diagnosis, I've backed off gluten almost entirely, but it's only been a couple of weeks.

Jestgar Rising Star

Maybe the best answer is that you caught this before you've done so much damage to your gut that all your numbers are high.

And I think the 'flagged A' means abnormal. not enough to call 'high', but enough to pay attention to.

sharps45 Apprentice

I think I'll go ahead and try to get in to see another doc. I'll try to find one around that knows something more than my current one. Thanks for the help!


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      Yes, an IgG panel is the logical next step. However, you would still need to be consuming normal amounts of gluten to ensure valid IgG testing. Since it has only been a week that you have been off gluten, there is still likely time to restore antibodies to detectable levels before the blood draw. IgG antibody tests are not quite as specific for celiac disease as are the IGA tests but they are certainly valuable in the case of IGA deficiency. They also seem to have a little more "staying power" in the sense of detecting celiac disease in the case of those who may have already started a gluten-free diet as long as they haven't been on it for an extended period of time. But don't rely on that. Get back on gluten if you can possibly endure it if you intend to go forward with IgG testing. This might be helpful:   
    • SEQ
      Thanks @trents. I have exchanged some messages with the clinic today, and they are saying that the reason there is no result for the total IgA levels is because I don't have any. Apparently a negative result means that it does not appear as a line on the results at all. I am not sure I buy this, but it is what they are telling me. I am leaning more towards the theory that they didn't test it in the first place. But, working on the basis that the test result was zero, I asked what the next steps would be, given that I apparently have no IgA antibodies. They have asked if I now want to have a tTG-IgG and a DGP-IgG test. Is this really the next step if I have no total IgA?
    • trents
      IGA deficiency is a lot more common than we used to think but I can't give you a number. Doctors used to believe it only happened in children but we know better now. Every doctor should order, at the very minimum, total IGA and tTG-IGA. It may be true that you don't have to worry as much about cross contamination if you have NCGS but that is not a given. By the way, welcome to the forum, @SEQ!
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