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Looking For Experienced Minds -- Does He Or Doesn't He?


w919oct

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w919oct Newbie
Hi, pugluver (LOVE the name!! :) )

Gluten intolerance is not an allergy. People who are gluten intolerant actually do have the same response (i.e., NOT a histimine response) as people who are celiac, and, unless they have a separate wheat allergy, will have negative allergy tests. The only official difference at this time is the villi damage.

If celiac is officially diagnosed by damaged intestinal villi, then what do you call it when all the symptoms are present and the villi are on their way to being damaged, but the damage is either not yet present or else not UNIFORMLY present (i.e., patchy, and therefore possible to miss)?

That is what the doctors have been calling, "gluten intolerance." In that type of scenario, gluten intolerance is just early-stage celiac.

If somebody gets mild symptoms from eating peanuts, they are allergic to peanuts. Nobody says, "Oh, let's wait until they have a full-blown anaphylactic reaction before we call it an allergy, and until then, it's just an intolerance."

Gluten intolerance can and does lead to other autoimmune disorders and cancer, because celiac IS a form of gluten intolerance. Just look at the huge numbers of people who have all the symptoms of celiac (but no positive biopsy, therefore no "official" diagnosis") AND diabetes, autoimmune thyroid disease, RA, MS, lupus, fibromyalgia, IBS, etc.

Even more compelling is the fact that DH (dermatitis herpetiformis) is also a definitive diagnosis of celiac disease--but many DH sufferers do NOT have villi damage and some don't even have intestinal symptoms. This strongly suggests that in celiac disease, the villi don't always get damaged, that the immune system can and does target anything and everything, from GI tract to thyroid to joints to pancreas to __________(fill in blank).

So, hopefully, someday, the researchers will conclude that looking for villi damage in order to conclusively diagnose celiac is ridiculous, as the immune system just might be targeting something other than villi, with gluten/celiac as the trigger.

If it walks like a duck, quacks like a duck, poops like a duck....


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    • knitty kitty
      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
    • rei.b
      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
    • knitty kitty
      Food and environmental allergies involve IgE antibodies.  IgE antibodies provoke histamine release from mast cells.   Celiac disease is not always visible to the naked eye during endoscopy.  Much of the damage is microscopic and patchy or out of reach of the scope.  Did they take any biopsies of your small intestine for a pathologist to examine?  Were you given a Marsh score? Why do you say you "don't have intestinal damage to correlate with lifelong undiagnosed celiac disease"?   Just curious.  
    • rei.b
      I was tested for food allergies and environmental allergies about 7 months before I started taking Naltrexone, so I don't think that is the cause for me, but that's interesting!  The main thing with the celiac thing that is throwing me off is these symptoms are lifelong, but I don't have intestinal damage to correlate with lifelong undiagnosed celiac disease.
    • trents
      Welcome to the forum, @Kara S! Warrior bread is a grain free bread product. Google it. There are commercial mixes available, I believe, Youtube videos and many recipes. 
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