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How To Interpret Transglutaminase (ttg) Igg

Amy Hull Brown

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Amy Hull Brown Rookie
Amy Hull Brown
Posted

My twin sons had been Gluten-free Casein-free for 2 1/2 months before we did celiac disease comprehensive bloodwork. The tests came back as follows:

Deamidated Gliadin Abs, IgA 1.0 (within range)

Deamidated Gliadin Abs, IgG 0.6 (within range)

t-Transglutaminase (tTG) IgA 1 (negative range)

t-Transglutaminase (tTG) IgG 9 HIGH (weak positive 6-9; positive >9)

Endomysial Antibody IgA negative

Immunoglobulin A, Qn, Serum 105 (within range)

Since they were Gluten-free Casein-free, I wasn't surprised that they showed negative on the IgA tests. But, how would you interpret their HIGH score on the tTG IgG?

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Rachel--24 Collaborator
Rachel--24
Posted

Were they tested for IgA deficiency (total serum IgA)?

If they are deficient in IgA....they would have negative IgA test results even if they have Celiac and even if they were still consuming gluten.

This is one possibility for negative IgA tests and positive IgG.

Also, its possible to have elevated tTG which is not caused by Celiac. tTG has been associated with other autoimmune conditions.

happygirl Collaborator
happygirl
Posted

Also could mean the damage done from Celiac (if we are going with the assumption he has Celiac) hasn't healed yet.

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