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Aga Iga (only Slightly Elevated )


chellbythesea

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chellbythesea Newbie

Just like everyone else, I would love to have a few opinions about my testing and symptoms that led me to test.

History: Infertility, diagnosed with Interstitial Cystitis (autoimmune disease) and endometriosis.

Blood work recently: only elevated is AGA IgA at 29 (normal is below 11) I hope I have the right test here. The doc said it's the least reliable for Celiac but the most sensitive if that helps.

Symptoms:

The above from my history plus fatigue, swollen eye lids and red and scaly, teeth recalcificatin (12 of them!) and some brown started to build up indicative of loss of minerals I think.

I do realize that the endoscopy will be a big help but wondering if anyone has been diagnosed with less than this for Celiac. If the AGA IgA is elevated and I have symptoms it just seems like it might be related or possibly I'm in the early stages.

Any info would be appreciated.


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ang1e0251 Contributor

When a dr goes to dx celiac disease, he must pull all the puzzle pieces at his disposal together. Symptoms just aren't enough as they can be vague, mimic other conditions and there are over 200 of them. You have few of the puzzle pieces already; symptoms and your blood work. But those are rather weak blood results. I think your dr will want an endoscopy and as it's a simple and, for me, painless experience, why not give him all the info he needs?

He could also dx on dietary response, family history and genetic testing but that's more of a stretch in your case. At least from the info you've provided. Consider the endo. Others might have some other suggestions.

nora-n Rookie

Before the ttg test, the antigliadin test was the usual test. A positive antigliadin test used to be enough to get the endoscopy done.

Some people only have one of the tests show up positive, and some none even though they do have a positive endoscopy w. biopsies.

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    • knitty kitty
      So you're saying that you think you should have severe intestinal damage since you've had the symptoms so long?   DGP IgG antibodies are produced in response to a partial gluten molecule.  This is different than what tissue transglutaminase antibodies are  produced in response to.   TTg IgA antibodies are produced in the intestines in response to gluten.  The tTg IgA antibodies attack our own cells because a structural component in our cell membranes resembles a part of gluten.  There's a correlation between the level of intestinal damage with the level of tTg antibodies produced.  You are not producing a high number of tTg IgA antibodies, so your level of tissue damage in your intestines is not very bad.  Be thankful.   There may be reasons why you are not producing a high quantity of tTg IgA antibodies.  Consuming ten grams or more of gluten a day for two weeks to two months before blood tests are done is required to get sufficient antibody production and damage to the intestines.  Some undiagnosed people tend to subconsciously avoid lots of gluten.  Cookies and cakes do not contain as much gluten as artisan breads and thick chewy pizza crust.  Anemia, diabetes and thiamine deficiency can affect IgA antibody production as well.   Do you carry genes for Celiac?  They frequently go along with EDS.
    • rei.b
      I was tested for celiac at the same time, so I wasn't taking naltrexone yet. I say that, because I don't. The endoscopy showed some mild inflammation but was inconclusive as to celiac disease. They took several biopsies and that's all that was shown. I was not given a Marsh score.
    • knitty kitty
      Food and environmental allergies involve IgE antibodies.  IgE antibodies provoke histamine release from mast cells.   Celiac disease is not always visible to the naked eye during endoscopy.  Much of the damage is microscopic and patchy or out of reach of the scope.  Did they take any biopsies of your small intestine for a pathologist to examine?  Were you given a Marsh score? Why do you say you "don't have intestinal damage to correlate with lifelong undiagnosed celiac disease"?   Just curious.  
    • rei.b
      I was tested for food allergies and environmental allergies about 7 months before I started taking Naltrexone, so I don't think that is the cause for me, but that's interesting!  The main thing with the celiac thing that is throwing me off is these symptoms are lifelong, but I don't have intestinal damage to correlate with lifelong undiagnosed celiac disease.
    • trents
      Welcome to the forum, @Kara S! Warrior bread is a grain free bread product. Google it. There are commercial mixes available, I believe, Youtube videos and many recipes. 
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