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Dq7 And Dq7

pat0301

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pat0301 Rookie
pat0301
Posted

I HAVE ASKED QUESTIONS BEFORE AND DID NOT GET A RESPONSE SO MAYBE SOMEONE WHO READS THIS WILL BE KIND ENOUGHT TO ANSWER. WHAT DOES IT MEAN WHEN YOU HAVE 2 0301DQ7 GENES? SHOULD I HAVE THE DQA1 CHECKED TO SEE IF ITS RELATED TO 0505.

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Lisa Mentor
Lisa
Posted
I HAVE ASKED QUESTIONS BEFORE AND DID NOT GET A RESPONSE SO MAYBE SOMEONE WHO READS THIS WILL BE KIND ENOUGHT TO ANSWER. WHAT DOES IT MEAN WHEN YOU HAVE 2 0301DQ7 GENES? SHOULD I HAVE THE DQA1 CHECKED TO SEE IF ITS RELATED TO 0505.

Here is some information on gene testing:

https://www.celiac.com/articles/21567/1/Ten...ting/Page1.html

Lisa16 Collaborator
Lisa16
Posted

There are people here who know lots more than I, but I have one dq7 and I am a diagnosed celiac. If you have the dq7 and you are sick, that's all you really need to know.

I don't know very much about alpha and beta parts of genes, but one of the dq7 genes (the 505) is considered by many here to be "half a celiac gene." Of course, having the gene doesn't mean you have the disease. It only means it is possible. I wouldn't pay for more testing myself unless you are trying to rule celiac out "legally" for some reason. Even then it won't tell you much because there are still a lot of things they do not know about genes and celiac. For example, there are diagnosed celiacs here who have genes other than 2, 8 and 7. You will find dq1. dq6 and dq9 often. In addition, some countries recognize some genes as "celiac genes" even if they are not recognized in this country.

From what I have read, in one study 2% of European celiacs tested had only the dq7 gene (no 2 or 8).

Perhaps that helps?

Hopefully somebody who knows more can answer you. There is one guy here who is a retired geneticist (search a few genetics threads and you will find him), but he doesn't feel testing for the genes is very helpful in disgnosis. He also doesn't feel it is right to call these genes "celiac genes." He can tell you more.

Good luck and save your money!

Lisa

pat0301 Rookie
pat0301
Posted
  • Author

Lisa,

Thank-you for your reply!! on my gene test it said i didn't have dq2 or dq8 and i had a extremely low chance of having celiac. My son had 0202 and 0301 and the said he had a low chance.

Lisa16 Collaborator
Lisa16
Posted

Pat-- if you are sick and going gluten free helped you, you must consider yourself a celiac.

"Low probability" is probably referring to the 2% study. But that is only one study. I imagine that if all celiacs everywhere were to get tested, the perceptions of "low probability" would have to revised upwards. And many more genes would have to be considered as factors.

I, for example, test as a dq6 and a dq7. Yet I have the disease. And there are people who only have the dq6 who have the disease too. Looking at dq2 and dq8 as the only possible culprits is blind. There are definitely many more factors involved.

So rather than looking only at the genes, we should be looking more at the dietary response. So perhaps you can take the money you would have spent on the test and buy you and your children lots of nice gluten free food. Lord knows it costs enough as it is.

Lisa

nora-n Rookie
nora-n
Posted

6% have half a gene. (in that european study)

Most DQ7 do have half a DQ2 gene (=the 05* alpha chain)

There have been at least two postings here by people who had the alpha chain tested and had this 05 alpha chain.

If you go to wikipedia.org and check the chart at the HLA DQ page, you see that many DQ7, but not all , do have the 05* alpha chain.

I wish Enterolab stopped telling people they do not have a celiac gene with DQ7.

Check out this recent post: https://www.celiac.com/gluten-free/index.php?showtopic=62050 note Kimball did the alpha chain testing

the person posting did have this celiac gene even though Enterolab wrote only gluten sensitive.

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