Can You Have Half A Dq8?

[val01 0]

Hi All,

I think that my subject topic covers my question. Can you have a half of a DQ8 (really asking on the alpha side)? Thanks so much!

Valerie

[nora_n 60]

The alpha chain is usually 03* but some can have 05* in the alpha chain as far as I can see....was that yhour question? the 05* alpha chain is quite celiac predisposing.

1 % of DQ8 can have this 05* alpha chain.

But your question sounds more like asking if you can still be DQ8 but only have half Dq8, like the 03* alpha chain, and wether the 03* alpha chain matters.

I will keep reading on it, since the half-gene issue has gotten more attention recently, insomuch that many labs now, except enterolab, started testing the alpha chains.

Here is more on DQ8 http://en.wikipedia.org/wiki/HLA-DQ8 and here in scandinavia and the german regions it is very frequent.

Which lab did your test?

if it is any lab ogher than enterolab, they might have your alpha chains, but did not tell you.

In teh articlea bout DQ7 and Sicily and celiac, maybe there is some answer to your question, but I will have to go and read it again.

Dq7, 8 and 9 differ just by one base they point out.

[val01 0]

Hi Nora,

Enterolab did my testing. I was debating whether I wanted to pay to have Promethus to do the DQ2/DQ8 test. I am very confused about my DQ 1,4 result as I am Irish, German, and British. When I asked about the DQ4, I understand that it's not limited to Asians but it's uncommon in Caucasians - and it's uncommon for with my ethnic background not to have at least one DQ2/DQ8 from what I understand. I was thinking perhaps there was an error maybe.

A) Gluten Sensitivity Stool and Gene Panel Complete *Best test/best value

Fecal Anti-gliadin IgA: 17 Units

Fecal Anti-tissue Transglutaminase IgA: 10 Units

Quantitative Microscopic Fecal Fat Score: Less than 300 Units

Fecal Anti-casein (cow's milk) IgA: 8 Units

HLA-DQB1 Molecular analysis, Allele 1: 0502

HLA-DQB1 Molecular analysis, Allele 2: 0402

Serologic equivalent: HLA-DQ 1,4 (Subtype 5,4)

I have never heard of anyone having the DQ8 on the alpha side - just a half of a DQ8, like the DQ2 halves you hear about.

I have read through Wikipedia on DQ4, DQ1. I also found this link - http://www.twinsuk.ac.uk/Publicatons/2008/ErlichH.Diabetes.%202008.pdf

I know this references diabetes, but I was mainly looking at the allelle patterns on Page 3. For example, you can have DQA1*0301, DQB1*0402 or DQA1 *0401, DQB1*0402 for DQ4, and for DQ1 - DQA1 *0102, DQB1 *0502. So, if you had DQA1*0301, could you have a half of DQ8 on the alpha side?

I hope I am making sense. Thank you for assistance.

Valerie

[nora_n 60]

yes, maybe 03* alpha could be half DQ8, or DQ3 maybe.

There was someone here who had a diagnosis some years back, and then got her genes tested for curiosity, and a child had DQ8, but tested negative.

She then contacted the lab and they re-did the test, I mean sent it on, and they found the DQ8. I guess the DQ8 is harder to find. Wikipedia says so too.

If you read around on DQ2 on wikipedia, there are some really strange DQ2 too. (they are now gone from the wikipedia page I think)

The person with the elusive DQ8 that had to be sent on, she said she also sent to enterolab and they found it no problem.

Yes, you should have some other gene than DQ4 with those acestors, and you should have a high chance of having DQ2 or 8. But some most have those other genes...

Here is the article about DQ7,8 and 9 (they have the 0301 alpha chain)