Enterolab

[Linma2428]

I had genetic test for celiacs a while back. I have looked over the test and really can't figure out what the numbers mean. I know it give interpertation that part I get but would like to know what all the numbers and letters mean. I had blood test for antibodies done but that test was normal didn't show any antibodies. I just wonder if Entrolab is a good lab. Did anyone use Entrolab and then find it was good on testing or not good on testing. I wonder if i should have the antibody test done again. I partly wonder because on regular ana testing i have a very high ANA 1:1280 homogeneous and they can't find out why say i don't have lupus or RA. I get upset stomach with D don't get constipation. But it seems to be connected to eating to much can't tell it has anything to do with gluten. I know if one has Celiac its much more involved than just not eating bread here and there. I had an upper gi and it was ok. I ask the doctor about the Genetic test results and he just said Oh you don't want to have that its a hassel to have. I didn't know what to say to that. Any way just trying to figure out what I need to do. I also have perinious anemia which is autoimmune but not sure if that could cause a high ANA or not.

That test said: Interpertation of HLA-DQ testing: HLA-DQB1 gene analysis reveals that you have one of the main genes that predisposses to gluten sensitivity and celiac sprue, HLA-DQB1*0201 or HlA-DQB1*0302. Each of your offspring has 50% chance of receiving this gene from you and at least one of your parents passed it to you. You also have a non-celiac gene predisposing to gluten sensitivity (any DQ1, DQ2 not by HLA-DQB1*0201 or DQ3 not by Hla-DQB1*0302). Having one celiac gene and on gluten sensitve gene, means that each of your parents and all of your children will possess at least one coply of a gluten sensitve gene. Having 2 copies also means there is a stronger predisposition to gluten sensitivity than having one gene and the resultant immunologic gluten sensitivity or celiac disease maybe more severe.

At the top it has

HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 Molecular analysis, Allele 2 0301

Serologic equivalent: HLADQ 2,3 (subtype2,7)

[Skylark]

HLA-DQB1 Molecular analysis, Allele 1 0201

HLA-DQB1 is the name of the gene they are testing. Your first copy is commonly called DQ2 and is a celiac gene. 0201 is the scientific designation. Having 0201 almost always means you're DQ2.5, which is a high risk gene for celiac.

HLA-DQB1 Molecular analysis, Allele 2 0301

This is your other copy and is more commonly called DQ7. 0301 is the scientific designation. It is sometimes inherited with another gene that can combine with your DQ2 to increase your risk for celiac, but Enterolab does not test for it.

Serologic equivalent: HLADQ 2,3 (subtype2,7)

This is Enterolab's weird of saying what genes you have. HLADQ 2,3 is a designation so outdated they shouldn't bother. Subtype 2,7 is where you get the DQ2 and DQ7 that are your genes.

So, in the terms the board usually uses, you are DQ2.5, and DQ7.

Enterolab's genetic tests are fine. They are actually done by the Red Cross. The stool antibody tests are extremely sensitive, to the point of sometimes getting false positives. Some people find them useful for double-checking their suspicions of gluten intolerance. They are not diagnostic for celiac.

Have you tried the gluten-free diet for any length of time? With the DQ2.5 it's reasonably likely you are at least gluten intolerant. If you have gluten intolerance, your gut is inflamed and sometimes just eating can set off trouble. Before you feel better, all the inflammation from the gluten has to settle down. It can take a few months being pretty strict on the diet to really tell.

[Linda56]

Thank you for clearing that up for me. I haven't really tried a strict gluten free diet. I assumed because the blood test wasn't positive that I didn't have much damage going on. But I am thinking of asking my doctor to check me when I have a colonoscopy if they can. I do have an upset stomach alot always have had. I did the stool test with Entrob lab first it was positive but low so then did the genetic test. Thanks again, Linda

HLA-DQB1 is the name of the gene they are testing. Your first copy is commonly called DQ2 and is a celiac gene. 0201 is the scientific designation. Having 0201 almost always means you're DQ2.5, which is a high risk gene for celiac.

This is your other copy and is more commonly called DQ7. 0301 is the scientific designation. It is sometimes inherited with another gene that can combine with your DQ2 to increase your risk for celiac, but Enterolab does not test for it.

This is Enterolab's weird of saying what genes you have. HLADQ 2,3 is a designation so outdated they shouldn't bother. Subtype 2,7 is where you get the DQ2 and DQ7 that are your genes.

So, in the terms the board usually uses, you are DQ2.5, and DQ7.

Enterolab's genetic tests are fine. They are actually done by the Red Cross. The stool antibody tests are extremely sensitive, to the point of sometimes getting false positives. Some people find them useful for double-checking their suspicions of gluten intolerance. They are not diagnostic for celiac.

Have you tried the gluten-free diet for any length of time? With the DQ2.5 it's reasonably likely you are at least gluten intolerant. If you have gluten intolerance, your gut is inflamed and sometimes just eating can set off trouble. Before you feel better, all the inflammation from the gluten has to settle down. It can take a few months being pretty strict on the diet to really tell.

[Skylark]

Thank you for clearing that up for me. I haven't really tried a strict gluten free diet. I assumed because the blood test wasn't positive that I didn't have much damage going on. But I am thinking of asking my doctor to check me when I have a colonoscopy if they can. I do have an upset stomach alot always have had. I did the stool test with Entrob lab first it was positive but low so then did the genetic test. Thanks again, Linda

You're welcome. Just so you know, it takes an endoscopy to check for celiac, not a colonoscopy. If you're "gluten light" there might not be much damage to diagnose.

You might be pleasantly surprised if you try the diet strictly.