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Transglutaminase Level >100


AnonymousTNMG

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AnonymousTNMG Newbie

I have recently picked up bloodwork results.

Six months ago, my Transglutaminase was >100.

Just last week, Doc ordered a couple more. My results were:

IGG 10.45 (ref range 7.0-16.0)

IGA 2.07 (ref range 0.7-4.0)

IGM 1.00 (ref range 0.4-2.30)

Transglutami nase >100 (ref range 0-20)

I have recently been diagnosed with Myasthenia Gravis, another autoimmune disorder. I am also hypothyroid-but it is under control with medication.

Looking for insight - does this mean I may have Celiacs? I have not received a follow-up call from my doc, but does this warrant one?

I have gone off wheat (not gluten) for a couple weeks here or there and have felt great.

Thank you!


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October3 Explorer

A high tTG, especially one above 100, is highly suggestive of celiac but that by itself isn't enough to diagnose. It can also be elevated with any number of other autoimmune disorders, so the fact that you have multiple autoimmune disorders can either mean you have celiac and that is causing some of the others, or you have a propensity toward autoimmune disorders and the tTG is reflecting that. I think if it were me I'd probably eliminate gluten for awhile and see what happens.

Mummyto3 Contributor

I'd say ring dr to find out where to go from here. My daughters ttg was 128. Her dr felt it was enough to diagnose her especially considering that she is very symptomatic. But after speaking to another dr, they will be doing a biopsy. Regardless of that result, she will be going gluten free (after biopsy).

TexasJenn Newbie

There is another blood test that is very specific for Celiac that you could ask for so you wouldn't have to do a biopsy. It is the EMA (endomysial antibodies) test. My tTG IGA was 92, and with the + EMA test my doctor said that the diagnosis is definitive even without a biopsy.

Good luck!

Jenn

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    • thejayland10
      thank you, i have been doing that the last few weeks and will continue to do so. I had not had my ttg iga checked since I was diagnosed 14 yrs ago so I am not sure if they ever dropped below the 15-20 range.    all my other labs are completely normal but I am concerned that this may be signs of refractor celiac or something else since I'm so careful with gluten-free diet 
    • Scott Adams
      Around 9% of celiacs cannot tolerate any oats, even gluten-free oats. It might be worth eliminating them for a few months, then get re-tested.
    • thejayland10
      I only eat certifed gluten-free products but a lot of which are processed. Could there be trace gluten in those or is that very unlikely? 
    • Scott Adams
      For people with celiac disease hidden gluten in their diets is the main cause of elevated Tissue Transglutaminase IgA Antibodies (tTG-IgA), but there are other conditions, including cow's milk/casein intolerance, that can also cause this, and here is an article about the other possible causes (you may want to avoid oats):    
    • thejayland10
      Hello,  I have seen numerous doctors and they can't seem to pin point why my ttg iga is still mildly elevated at 16-20 even after being gluten free for over 10 years. I follow a very strict diet and don't eat out. All my other blood tests such as ema, DGP IGA / IGG, vitamin levels, CBC, and dexa scan were normal. 
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