Just Got Tested. What Does This Mean?

[Makimonaco1]

Hello,

My doctor just finished testing me and got my results via e-mail. I can not go back to him before 6 weeks for work reasons and I would like to know what these results mean:

IgA - 283.00 mg/dl

[Makimonaco1]

Hello,

My doctor just finished testing me and got my results via e-mail. I can not go back to him before 6 weeks for work reasons and I would like to know what these results mean:

IgA - 283.00 mg/dl

CELIAC SCREEN - 42.2 U/ml (Includes TTG and DGP)

Transglutaminase_IgA - 7.50 EU/ml (IgA isotype of TTG)

ENDOMYSIAL Ab - NEGATIVE

Vitamin D - 31.4 nmol/L

Vitamin B-12 - 482 pmol/L

Thanks.

[Skylark]

We can't interpret any labs without the normal ranges. That looks like a normal total IgA, but if that's the case all it says is that your celiac panel would be valid.

[Makimonaco1]

Hello,

Thanks for responding so fast. The results plus the lab normal ranges are as follow:

IgA - 283.00 mg/dl (NORMAL IS 70 TO 500)

CELIAC SCREEN - 42.2 U/ml (Includes TTG and DGP) (NORMAL IS 0 TO 40)

Transglutaminase_IgA - 7.50 EU/ml (IgA isotype of TTG) (NORMAL IS 0 TO 20)

ENDOMYSIAL Ab - NEGATIVE (IgG+IgA iso. of endomys)

Vitamin D - 31.4 nmol/L (NORMAL IS 75 TO 250)

Vitamin B-12 - 482 pmol/L (NORMAL IS 156 TO 672)

Thanks.

[Skylark]

Ah, that makes more sense.

You have a low positive on the celiac screen, but the other two major celiac tests (TTG and endomysial) are negative. The DGP test in the celiac screen is the most sensitive of the three tests by far, so it is reasonably common to be celiac with a positive result on only that one test. It means you have antibodies to DGP (deamidated gliadin peptide). DGP is only produced in your intestine if you either have celiac disease or are on the way to developing it. If I had your panel, I would ask my doctor for a referral to a GI for a biopsy to see what's going on. You need to keep eating gluten in order to get an accurate biopsy.

Your vitamin D is low, which isn't unusual. You can email your doctor right now and ask how much D3 he recommends. Mine was at 28 and they started me on 2,000 IU a day. You can start taking the vitamin D right away. The little liquid capsules are supposed to be better than dry pills.

Once the biopsy is over, if I were you I would go gluten-free. It's possible to have a false positive lab test but even if the biopsy doesn't turn up anything I would find the DGP worrisome as far as continuing to eat gluten.

[Makimonaco1]

Thank you very much for your help. I will follow your advise.