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Test Results


carmenm

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carmenm Newbie

I received my 11 year old daughter's test results if anyone can explain for me I appreciate any help I can get...her Dr. told me that she was positive with a blood test, did the biopsy and since that is "negative" they are saying she is not Celiac

As it is written on here:

IgA Total is 162 mg/dL

tTG Ab, IgA shows *H 35.3 unit/m

can anyone tell me what those mean, and what the numbers should be for someone who is "normal"?

As far as the biopsy report goes it says the following:

1. Small bowel boipsy for disacchiaridases sent to The Medical College of Wisconsin

- consisted of two tan pink to red tissue fragments .2 and .3 cm

SMALL BOWEL BIOPSY SPECIMEN SENT TO MEDICAL COLLEGE OF WISCONSIN FOR DISACCHARIDASES DETERMINATION. SEPARATE REPORT WILL FOLLOW.

2. Biopsy second portion of duodendum.

- consists of four pink-tan tissue fragments .2 - .3 cm

SECOND PORTION OF DUODENUM BIOPSY: FRAGMENTS OF SMALL INTESTINAL MUCOSA WITH NO SIGNIFICANT HISTOLOGIC ABNORMALITY

3. Biopsy duodenal bulb.

- consists three pink-tan tissue fragments .2, .3 cm

FRAGMENTS OF SMALL INTESTINAL MUCOSA WITH NO SIGNIFICANT HISTOLOGIC ABNORMALITY

4. Biopsy antrum of stomach.

- consists of two pale pink tissue fragments .2 and .5cm

FRAGMENTS OF GASTRIC MUCOSA WITH NO SIGNIFICANT HISTOLOGIC ABNORMALITY

GIEMSA STAIN FOR HELICOBACTER PYLORI-LIKE ORGANISMS IS NEGATIVE

5. Biopsy distal esophagus.

- consists of two white tissue fragments .3 and .4 cm

FRAGMENTS OF SQUAMOUS MUCOSA WITH NO SIGNIFICANT HISTOLOGIC ABNORMALITY.

Thanks again, if I should be including anything else, please let me know and I can look for it on these papers.


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gfcolorado Newbie

I received my 11 year old daughter's test results if anyone can explain for me I appreciate any help I can get...her Dr. told me that she was positive with a blood test, did the biopsy and since that is "negative" they are saying she is not Celiac

As it is written on here:

IgA Total is 162 mg/dL

tTG Ab, IgA shows *H 35.3 unit/m

can anyone tell me what those mean, and what the numbers should be for someone who is "normal"?

As far as the biopsy report goes it says the following:

1. Small bowel boipsy for disacchiaridases sent to The Medical College of Wisconsin

- consisted of two tan pink to red tissue fragments .2 and .3 cm

SMALL BOWEL BIOPSY SPECIMEN SENT TO MEDICAL COLLEGE OF WISCONSIN FOR DISACCHARIDASES DETERMINATION. SEPARATE REPORT WILL FOLLOW.

2. Biopsy second portion of duodendum.

- consists of four pink-tan tissue fragments .2 - .3 cm

SECOND PORTION OF DUODENUM BIOPSY: FRAGMENTS OF SMALL INTESTINAL MUCOSA WITH NO SIGNIFICANT HISTOLOGIC ABNORMALITY

3. Biopsy duodenal bulb.

- consists three pink-tan tissue fragments .2, .3 cm

FRAGMENTS OF SMALL INTESTINAL MUCOSA WITH NO SIGNIFICANT HISTOLOGIC ABNORMALITY

4. Biopsy antrum of stomach.

- consists of two pale pink tissue fragments .2 and .5cm

FRAGMENTS OF GASTRIC MUCOSA WITH NO SIGNIFICANT HISTOLOGIC ABNORMALITY

GIEMSA STAIN FOR HELICOBACTER PYLORI-LIKE ORGANISMS IS NEGATIVE

5. Biopsy distal esophagus.

- consists of two white tissue fragments .3 and .4 cm

FRAGMENTS OF SQUAMOUS MUCOSA WITH NO SIGNIFICANT HISTOLOGIC ABNORMALITY.

Thanks again, if I should be including anything else, please let me know and I can look for it on these papers.

From my understanding, the IGA Total is just to determine if you are IGA deficient or not so that they can test for other tests. Does it have a range for the TTG IGA tests?

The mayo clinic is an excellent resource on Celiac testing. Here is a link with algorithms for different testing scenerios:

Open Original Shared Link

I'm not in the medical field but have done a lot of research. You may want to see about getting her tested again with a different test (DGP IGA) and/or see if a different pathologist can review the pathology. One of the things that I've learned and didn't know is that biopsy reading is not black and white.

Good luck and let us know how it goes.

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    • trents
      Let me hasten to add that if you will be undergoing an endoscopy/biopsy, it is critical that you do not begin efforts to reduce gluten beforehand. Doing so will render the results invalid as it will allow the small bowel lining to heal and, therefore, obscure the damage done by celiac disease which is what the biopsy is looking for.
    • Scott Adams
      This article, and the comments below it, may be helpful:    
    • Scott Adams
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      https://celiac.org/glutenexposuremarkers/    yes, two hours after accidents ingesting gluten I am vomiting and then diarrhea- then exhaustion and a headache. see the article above- There is research that shows our reactions.
    • trents
      Concerning the EMA positive result, the EMA was the original blood test developed to detect celiac disease and has largely been replaced by the tTG-IGA which has a similar reliability confidence but is much less expensive to run. Yes, a positive EMA is very strong evidence of celiac disease but not foolproof. In the UK, a tTG-IGA score that is 10x normal or greater will often result in foregoing the endoscopy/biopsy. Weaker positives on the tTG-IGA still trigger the endoscopy/biopsy. That protocol is being considered in the US but is not yet in place.
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