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Alvine's ALV003 Named a Top 10 Inflammatory/Autoimmune Project to Watch by ... - FierceBiotech


Scott Adams

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FierceBiotech

(BUSINESS WIRE)-- Alvine Pharmaceuticals, Inc., a biopharmaceutical company focused on the treatment of autoimmune and gastrointestinal diseases, announced today that the company's lead therapeutic product candidate for celiac disease, ALV003, ...

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    • MagsM
      Hi Trents, yes classic Alzheimer's is caused by plaque build up but the diagnosis of Alzheimer's often covers other types of cognitive decline including mild cognitive impairment, short term memory loss and vascular dementia which are all of the issues that my Mom has. She does not show any plaque build up on MRI. 
    • trents
      Alzheimer's is caused by a buildup of beta amyloid plaque tangles in the neurons. I don't see how that would be influenced by hearing loss. I can see where sensory deprivation could contribute to mental decline in indirect ways but Alzheimer's is a disease with a biochemical base.
    • MagsM
      Thank you all for your feedback. I did see the Consultant Otolaryngologist today and unfortunately she is not doing any research into potential functional immune or inflammatory mechanism that could be driving Ménière’s. My Mom was diagnosed with Meniere's at my age (58) and then did develop Alzheimer's in her 70's. The consultant mentioned that my Mom's Alzheimer's could have been triggered from the hearing loss due to the Ménière’s. She then went into worst case scenarios which freaked me out entirely (full hearing loss and cochlear implants)! Apparently it is very important to keep those neural pathways (hearing, balance vision etc.) fully functional to stave off potential brain...
    • Scott Adams
      Your frustration is completely understandable—after 13 years of strict gluten-free living and mostly normal antibody levels, it’s disheartening to still see biopsy evidence of lingering damage, especially without clear guidance from your GI. The subtle improvements (like "focal" vs. "patchy" changes) might suggest some healing, but the persistent villous blunting and lymphocytosis raise valid concerns about ongoing low-level inflammation, cross-contamination, or even refractory celiac disease (though your normal antibodies make this less likely). It’s especially frustrating when your symptoms (nausea, pain) are dismissed with generic advice, and communication feels like a game of telephone...
    • Pablohoyasaxa
      Thanks for the post on Vitamin D.  I have been living in south Florida and have been taking moderately higher doses of vit D. I am considering the Mushroom supplements and exporing Real Mushrooms, the brand. Not sure. If you have any thought, please share. I am curious about all things homeopathic. 
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