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Biopsy Results


boyzx3

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boyzx3 Newbie

Hello. I'm new to the board, today. My son (13yo) was given a firm diagnosis last week with having celiac. We stared the gluten free diet last Thursday. It hasn't been too bad, I must say. I cleaned the heck out of my kitchen. I threw away tupperware, baking dishes, pots/pans, and cutting boards. We are waiting on results for blood work for the other 2 kids.

I'm looking for a little understanding on something the doc said to us. Hopefully you can help. He said something about mesh rating of 3a on a scale of 1-3b. Is this basically the amount of damage he has?

Thanks for your help.

Jeanette


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pricklypear1971 Community Regular

Yes, look under diagnosis/endoscopy.

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Bubba's Mom Enthusiast

Hello. I'm new to the board, today. My son (13yo) was given a firm diagnosis last week with having celiac. We stared the gluten free diet last Thursday. It hasn't been too bad, I must say. I cleaned the heck out of my kitchen. I threw away tupperware, baking dishes, pots/pans, and cutting boards. We are waiting on results for blood work for the other 2 kids.

I'm looking for a little understanding on something the doc said to us. Hopefully you can help. He said something about mesh rating of 3a on a scale of 1-3b. Is this basically the amount of damage he has?

Thanks for your help.

Jeanette

The Dr. was telling you about the level of damage according to the Marsh scale.

From Wikipedia:

The classic pathology changes of coeliac disease in the small bowel are categorised by the "Marsh classification":[62]

Marsh stage 0: normal mucosa

Marsh stage 1: increased number of intra-epithelial lymphocytes, usually exceeding 20 per 100 enterocytes

Marsh stage 2: proliferation of the crypts of Lieberkuhn

Marsh stage 3: partial or complete villous atrophy

Marsh stage 4: hypoplasia of the small bowel architecture

Marsh's classification, introduced in 1992, was subsequently modified in 1999 to six stages, where the previous stage 3 was split in three substages.[63] Further studies demonstrated that this system was not always reliable and that the changes observed in coeliac disease could be described in one of three stages

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    • trents
      So the tTG-IGA at 28 is positive for celiac disease. There are some other medical conditions that can cause elevated tTG-IGA but this is unlikely. There are some people for whom the dairy protein casein can cause this but by far the most likely cause is celiac disease. Especially when your small bowel lining is "scalloped". Your Serum IGA 01 (aka, "total IGA") at 245 mg/dl is within normal range, indicating you are not IGA deficient. But I also think it would be wise to take your doctor's advice about the sucraid diet and avoiding dairy . . . at least until you experience healing and your gut has had a chance to heal, which can take around two years. After that, you can experiment with adding dairy back in and monitor symptoms. By the way, if you want the protein afforded by dairy but need to avoid casein, you can do so with whey protein powder. Whey is the other major protein in dairy.
    • jenniber
      hi, i want to say thank you to you and @trents   . after 2 phone calls to my GI, her office called me back to tell me that a blood test was “unnecessary” and that we should “follow the gold standard” and since my biopsy did not indicate celiac, to follow the no dairy and sucraid diet. i luckily have expendable income and made an appt for the labcorp blood test that day. i just got my results back and it indicates celiac disease i think 😭   im honestly happy bc now i KNOW and i can go gluten free. and i am SO MAD at this doctor for dismissing me for a simple blood test that wouldn’t have cost her anything !!!!!!!!!!! im sorry, im so emotional right now, i have been sick my whole life and never knew why, i feel so much better already   my results from labcorp:   Celiac Ab tTG TIgA w/Rflx Test Current Result and Flag Previous Result and Date Units Reference Interval t-Transglutaminase (tTG) IgA 01 28 High U/mL 0-3 Negative 0 - 3 Weak Positive 4 - 10 Positive >10 Tissue Transglutaminase (tTG) has been identified as the endomysial antigen. Studies have demonstrated that endomysial IgA antibodies have over 99% specificity for gluten sensitive enteropathy. Immunoglobulin A, Qn, Serum 01 245 mg/dL 87-352
    • JoJo0611
      Thank you this really helped. 
    • Samanthaeileen1
      Okay that is really good to know. So with that being positive and the other being high it makes sense she diagnosed her even without the endoscopy. So glad we caught it early. She had so many symptoms though that to me it was clear something was wrong.   yeah I think we had better test us and the other kids as well. 
    • GlorietaKaro
      One doctor suggested it, but then seemed irritated when I asked follow-up questions. Oh well—
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