- Celiac Disease Research: Associated Diseases and Disorders
- Depression and Celiac Disease
- Reversal of Psychopathology in Adult Coeliac Disease with the Aid of Pyridoxine (vitamin B6) - Scandinavia
Reversal of Psychopathology in Adult Coeliac Disease with the Aid of Pyridoxine (vitamin B6) - Scandinavia
In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease, and since then it has become an invaluable resource to people worldwide who seek information about celiac disease and the gluten-free diet.
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Source: Scandinavian Journal
of Gastroenterology, 18:(2):299-304, 1983 Mar.
Authors - Hallert C., Astrom J., Walan A.
of mental depression are typical in adults with coeliac disease.
The response to treatment was evaluated in 12 consecutive patients
by means of the Minnesota Multiphasic Personality Inventory
(MMPI), with surgical patients serving as controls. The coeliacs
reported no change in depressive symptoms after 1 years gluten
withdrawal despite evidence of improvement in the small intestine.
When re-tested after 3 years, however, after 6 months of 80mg/day
of oral pyridoxine (vitamin B6) therapy, they showed a fall
in the score of scale 2 (depression) from 70 to 56 (p less
than 0.01), which became normalized like other pretreatment
abnormalities in the MMPI. Cholecycstectomy in the control subjects
produced no alterations in the MMPI profile. The results indicate
a causal relationship between adult coeliac disease and concomitant
depressive symptoms which seems to implicate metabolic effects
from pyridoxine deficiency influencing central mechanisms regulating
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