Celiac.com 05/06/2008 - In the majority of people with celiac disease, strict adherence to a gluten-free diet can result in a quality of life that is on par with non-celiacs. Still a small percentage of celiacs seem to suffer from persistent gastrological discomfort in the form of irritable bowel or irritable-bowel-like symptoms. Very few studies have been done on persistent gastrological problems in adults with celiac disease. Those that have been done rely upon univariate statistical analysis in clinical samples at the secondary or tertiary care level and fail to assess the potential influence of non-celiac disease specific factors, which are considered to be a risk factor of irritable bowel syndrome (IBS), such as mental disorders, or gender.

A team of researchers made up of doctors Winfried Hauser, Frauke Musial, Wolfgang Caspary, Jurgen Stein, and Andreas Stallmach set out to determine rates of irritable bowel syndrome, irritable bowel syndrome-related symptoms, and consecutive health care-seeking behavior and their influence upon health-related quality of life (HRQL) and any conceivable bio-psychosocial factors influencing adult patients with celiac disease. The research team made a medical and socio-demographic survey of 1000 adult celiac patients from the German Celiac Society by post. The medical portion of the survey included bowel history. The team also had patients fill out a Short Form Health Survey (SFHS), along with the Hospital Anxiety and Depression Scale.

516 of the questionnaires came back completed. Respondents were similar in gender ratio and median age from the whole membership directory of the German Celiac Society, a group of more than 18,000 people who reported suffering from celiac disease at the age of 18. Of these, 213 (41.3%) had a diagnosis of celiac disease that was made by a duodenal biopsy, 37 (7.2%) by serological tests (celiac disease-specific antibodies), 34 (6.6%) using stool tests for trans-glutaminase antibodies, and 232 (45.0%) using