Get email alerts Get E-mail Alerts Sponsor: Sponsor:

Ads by Google:

   Get email alerts  Subscribe to FREE email alerts

  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   09/30/2015

      This FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Store.

Biopsy Positive (?), Anemia, Confusion With Blood Tests Igg Igb Etc.

5 posts in this topic

Hi everyone, I've been reading and following this forum for a while now and would really appreciate help with my current predicament.

I had an upper and lower endoscopy a year ago for Gastroparesis. I recently found out that the biopsy of small intestine showed inflammation and positive sign for possible Celiac. I have no idea what that means, if it's just inflammation or the villi.

I have had all the symptoms of celiac disease for about 15 years but the last year and a half have become severe. I have lost 147 pounds in 18 months which they think is from Gastroparesis although that testing was inconclusive. I can only eat a few foods right now and have absolutely no appetite. I am also anemic and have low B12.

Inflammatory markers in serum are positive and also have a positive ANA with homogenous titer pattern.

Was diagnosed with Primary Sjogrens last week and he also suspects Celiac and maybe Lupus. But my blood tests are confusing me. (haven't seen the doc again yet)

Both my TTG IGg A and IGg Ab show my level at >10 with the 'standard range' listed as >20. Does this mean that my levels are low and that I don't have Celiac?

My Beta globulins are also low.

I sure hope I don't as bread and crackers are among the things I can still eat!

My mother was told she was allergic to wheat when she was in her late 40's. I don't know if she actually had testing or if she and her doctor just figured that out using an elimination diet without testing. Don't know if she had celiac disease.

What do my blood tests mean?

Thanks, Lois


Share this post

Link to post
Share on other sites

Well, I do have to admit that that is a very confusing way to report a test result. It means that your antibodies are greater than 10, but does not tell you by how much. To be positive they would have to be greater than 20. Whether that score represents somewhere between 10 and 20 is not at all clear. They should be able to quantify an exact number for you. They also did only one test (well, two if you count the IgA and IgG versions) when a full celiac screening panel consists of the following:

Anti-Gliadin (AGA) IgA

Anti-Gliadin (AGA) IgG

Anti-Endomysial (EMA) IgA

Anti-Tissue Transglutaminase (tTG) IgA

Deamidated Gliadin Peptide (DGP) IgA and IgG

Total Serum IgA

Bearing in mind the following: The first two tests are the older tests and have been largely replaced by the DGP; and the EMA is usually only run when the tTG is positive, they have not run the newer test, the DGP which is very specific for celiac disease and shows up at an earlier stage than the tTG, and the Total Serum IgA shows whether or not you produce normal quantities of antibodies. But all that aside, you do not have to test positive on all tests. Only one positive is required, and for someone with such longstanding symptoms as yours, with signs of GI damage (??celiac) a year ago, with such a drastic weight loss which is one of the biggie symptoms of celiac (although could be caused by gastroparesis), the anemia and low B12, another autoimmune disease (Sjogrens) and suspicion of lupus, family history of wheat allergy, I would think they absolutely run a total panel on you, along with another EGD with biopsy.

So what does it all mean? At this point, nothing useful. You need to talk to your doctor about it, obviously, but at this point I would think the whole panel is called for rather than just a screening tTG which is the way the doctors usually like to go. But they don't have to live in your body and can afford to say, well, we'll just save some money and run this one test. It is possible for this test to be entirely negative and for you to have celiac disease. It is possible also for this test to be positive and for you to not have the disease, so just running this one test does not tell you a lot of anything.

If you doc is willing to cut to the chase and do another EGD, and take at least six biopsy samples, then do that by all means; it is certainly justified with your dramatic symptoms in the last 18 months. Let us know what your are told after your visit. Welcome to the board and keep in touch and let us know how your testing progresses.


Share this post

Link to post
Share on other sites

Thank you so much for your response and help!

Those two tests are so confusing. The 'standard range' part is confusing, does that mean that normal is above 20 or that to be positve it has to be above 20. Very ambiguous to me. Usually a test will have either a 'reference range' or 'standard range'. This particular University has old testing procedures for some reason.

I just checked and he didn't run the DGP or EMA. I will ask when I see him next month.

I wish the biopsy was more specific too, don't understand why something positive isn't enough for a diagnosis. Can't tell you how often I have tested positive for something but then told only to be told it wasn't significant enough.

I just hate waiting.


Share this post

Link to post
Share on other sites

Normally there are three parts to the range: for example, >5 would be negative; 6-9 would be equivocal or mildly positive; <10 would be positive. They usually put in this equivocal range because how can you say that 10 is that much greater than 9 :rolleyes: ?? or 6 that much greater than 5. I guess you could call it a cover your butt range :) But I have never seen scores expressed like yours.

Do you have a copy of the pathology report that you could reproduce here? (The one for the EGD?)


Share this post

Link to post
Share on other sites

Normally there are three parts to the range: for example, >5 would be negative; 6-9 would be equivocal or mildly positive; <10 would be positive. They usually put in this equivocal range because how can you say that 10 is that much greater than 9 :rolleyes: ?? or 6 that much greater than 5. I guess you could call it a cover your butt range :) But I have never seen scores expressed like yours.

Do you have a copy of the pathology report that you could reproduce here? (The one for the EGD?)

Yeah, this particular medical system has a long history of old methodology in testing and treatment even though it's a teaching hospital. Go figure.

I don't have the pathology report but that's what I am going to do tomorrow. I will post it as soon as I have it. My suspicion is that they only took one biopsy. Thanks again!


Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • Forum Statistics

    • Total Topics
    • Total Posts
  • Topics

  • Posts

    • Possible celiac? Frustrated and upset
      Hi everyone, I'm new to this forum but I think I may have coeliac disease, the doctors say it could be anyway or possibly h pylori  Constant pain above my navel, nausea, anaemia, joint pain, bloating, migraines, depression, mood changes, feeling "not all there" and feeling so tired I could sleep all day! I just don't want to get out of bed let alone the house  these are just a few symptoms I have to cope with every single day! It's so frustrating! I just want to feel normal!!! I also have what feels like a lump in my throat at times and excess mucus all the time. Ive been suffering from this for years now, not this bad of course. And I've got the common answers from the doctors "it's IBS, excess stomach acid" you name it..  Recently I went to the doctors and persisted, pretty much begged for further tests as I couldn't deal with it much longer! I'm waiting on blood results and have a scan soon. Possibly an endoscopy depending on my blood test results.  Im just wondering if any of you have the symptoms I do? Thank you in advance  
    • Secret Deodorant
      I never worry about deodorant.  The only things you really need to worry about are things that might get in your mouth.  I get shampoo in my mouth so I read the ingredients.  They will say if they have wheat germ oil in them.   "Gluten must be ingested to be cause for concern for someone with celiac disease. We still recommend those with celiac disease avoid contact with gluten, especially with products that have the potential to be ingested. Small amounts of gluten can be found in many cosmetics, lotions and shampoos. Avoid product ingredients that literally say “wheat,” “rye,” “malt” or “barley.”  "
    • Secret Deodorant
      Most toiletry products are fine even if they have wheat/gluten in them.  The main issue is not to ingest them!  Many folks with celiac disease are careful with shampoo, conditioner, soap, lotion, lipstick, lip gloss, hair products,  and sunscreen because they could be accidentally swallowed (if you chew on your nails, etc.).   I have used Crystal Deodorant for 20 years now.  It can last for years!  Seriously!  It is pretty effective but not as effective for a teenager.   My entire family uses it, but my teen uses regular antiperspirant too.  You can find it at Whole Foods, Sprouts, healthfood stores, and even a "roll" on version at CVS.  Of course, Amazon carries it too and the price is comparable to the stores.   I found some mini travel versions at Marshalls (but that is hit or miss).  I like the solid crystal option the best.  I really like Gabriel Lipstick found at Sprouts.  I buy it on sale.  It is certified gluten-free, so I never have to worry!  I hear that Red Apple (sold online) is very good too and is certified.   I hope this helps!  
    • Anyone Else Feel A "lump" In Their Stomach?
      Hi chinup,  I know it's been a while, but I was wondering if what was the diagnosis.. Please let us know.  Thank you! 
    • Tests done, waiting for CT Scan and Biopsy appointments
      Hello, I have been reading a lot of posts while waiting for some of my test results to come back.  So thankful for the information I have found so far! I have completed my blood tests and other lab work.  Complete allergy tests came back positive for all in the bread/cereal profile.   One of the gene tests for Celiac came back positive and one other test came back high, even though I was not eating Gluten at the time of my lab work.  Back eating a small amount of gluten daily and have CT Scan and biopsy appointments scheduled for the near future.   I was wondering if anyone else is where I am as far as the testing.  I have had quite a few symptoms return quickly after going back to eating gluten.  The next day I had a migraine headache for the entire day, went to sleep and woke up with another headache that wasn't quite as bad.  Prior to my appointment,  I was only gluten free for 2 months and was really starting to feel great.  Three days into eating gluten stomach cramps returned.  Also on a Low FODMAP diet.  Unfortunately had to go back to eating it for the biopsy test.   Please reply if you are in the same spot as me as far as testing for Celiac.  Thanks, Sheila 
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
    • Most Online

    Newest Member