Still Confused About Test Results
Posted 09 November 2009 - 07:23 AM
My daughter's results showed antigliadin IgA antibody was elevated. She does not have high enough intestinal IgA antibodies to show an autoimmune reaction, which is strange because she has autoimmune symptoms. She also had a positive genetic test which shows that she has the gene predisposing her to both Celiac and gluten insensitivity.
I truly believe that my daughter is sensitive to gluten but I'm trying to figure out an explanation to tell other people how she can be gluten insensitive but not Celiac.
Posted 09 November 2009 - 07:58 AM
If evolution really works, how come mothers only have two hands?" - Milton Berle
"Life is 10 percent what happens to me and 90 percent how I react to it."--Lou Holtz
Posted 09 November 2009 - 08:07 AM
- James Watson
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Posted 15 December 2009 - 05:41 AM
Posted 15 December 2009 - 04:00 PM
It's a recording of a presentation by the William K. Warren Medical Research Center for Celiac Disease. In it the director, Martin F. Kagnoff, M.D., talks about different sensitivities to gluten
Celiac - classically the symptoms of intestinal damage and associated diarrhea, nutritional deficiencies, bloating, headaches, and failure to thrive in kids. In this case the blood tests will show high IgA unless there is a deficiency of overall IgA, which has to be tested for. There is also cryptic celiac with few or no symptoms, possibly negative labs and intestinal biopsy. If you did a genetic study these people have the markers though. According to a Mayo study some kind of damage is still happening because people with this kind die earlier than people without any response. Also, lab tests and even intestinal biopsy will be negative if the person has been on a gluten free diet.
Then there is Gluten sensitivity - same symptoms as classical celiac - gas, abdominal bloating and discomfort, diarrhea, headaches and so on, but blood tests are negative. He says at the end in the question time that since gluten molecules are huge it could just be a reaction to a different part of the molecule and wouldn't show with the standard tests. From the doctor's point of view they want to do all the tests including a gluten challenge of two months on gluten then repeating the blood work and intestinal biopsy. The treatment is just gluten dietary avoidance.
Finally he talks about wheat allergy which can be a reaction to other parts of the gluten molecules or other parts of wheat or can be mediated by a different part of the immune system - IgE or T cells. Again as doctors they'd like patients to do the full gluten challenge and testing but the treatment is dietary avoidance. The most dangerous type of this can produce anaphylactic shock in people who exercise after wheat ingestion (!).
Long story short...no test is definitive for all kinds of gluten or wheat reactions. Hope that is helpful.
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