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Help Interpret Results Please!

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Posted 08 July 2010 - 10:08 AM

Please, if anyone can help me to understand these test results:

Molecular Analysis of DQA1 Genotype:
0501 (HLA-DQ2) Gluten Sensitivity Positive: Yes

Molecular Analysis of DQB1 Genotype:
0201 (HLA-DQ2) Gluten Sensitivity Positive: Yes
0202 (HLA-DQ2) Gluten Sensitivity Positive: Yes

If you could just explain in simple enough terms that this "right brained" person could understand! Thanks!!
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Posted 08 July 2010 - 11:35 AM

You have tested positive for DQ2.5 a simple google search will reveal much more in-depth knowledge of that specific marker but basically it's the most potent gene for producing an immune system response to gluten. Your test unfortunately doesn't tell you if you have two copies of the gene (one from both parent) so it doesn't tell you the likelyhood of your ability to pass it on to your offspring but even just one copy of it is strong enough to cause problems in a lot of people.
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Receiving a qualified diagnosis of Irritable Bowel Syndrome is as useful as a Psychiatrist giving you a diagnosis of "Doesn't Think Right".




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Posted 08 July 2010 - 11:38 AM

Hi there. It's a genetic test result. Your test shows that you have some immune system genes that are associated with celiac disease. One, called DQ2.5, (Your DQB1*0201 and DQA1*0501 alleles) is the subject of a lot of interest and research. It's common in people of Northern European descent and a lot of people with celiac disease have it. Your other allele, DQB1*0202 is also associated with celiac and is often part of pair called DQ2.2.

The genes are not a guarantee that you have or will develop celiac disease at all, but there was a pretty big study where 28% of the people with your set of genes and a lot of stomach trouble had celiac disease. Many other people with your genes are gluten intolerant and simply feel healthier and better when they stop eating gluten.

Basically, if you think you have trouble with gluten it's totally NOT in your head. :)
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